Bromley wrote:What is the basis for the assumption that ms involves the immune system or is an auto-immune disease?
To determine whether relapsing or progressive EAE can occur in the absence of epitope spreading, we evaluated the course of disease in mice which possessed only a single myelin-specific TCR. These mice (transgenic/SCID +/+) exhibited a progressive and sometimes remitting/relapsing disease course in the absence of immune reactivity to multiple, spreading myelin epitopes.
katie45 wrote:...I've been screaming this for years. The human body (in my opinion) does not attack itself. Simply because "they" cannot find the pathogen with the current testing available does NOT mean it isn't there...I believe the human body/brain has only so many ways to manifest a response to an invasion. Thus all the labels..fibro, Chronic fatigue syndrome (now there's a well thought out scientific label) MS, parkinsons etc...I also believe many, if not all of these so called diseases are inflamatory responses.
katie45 wrote:I've been screaming this for years. The human body (in my opinion) does not attack itself.
Walker, L.S. and Abbas, A.K. 2002. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol 2(1):11-19.
The remarkable capacity of the mammalian immune system to coordinate deadly attacks against numerous invading pathogens, yet turn a blind eye to self-tissues continues to fascinate immunologists. It has been clear for some time that immune cells capable of recognizing self-proteins exist in normal individuals without seemingly causing harm. The 'peripheral tolerance' mechanisms that keep these cells in check are the focus of intense research, not least because defects in these pathways might cause autoimmune diseases. In this review, new developments in our understanding of peripheral tolerance are discussed.
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