This "response by ThisIsMS.com" is riddled with holes. The MS society has no motives beyond helping people with MS, UNLIKE the charlatans that sell LDN on the internet.
1) arguing about whether LDN was approved since the "early 1990's" or "1995". Uh... the MS society is giving you the benefit of the doubt saying early 1990's while THisIsMS argues that it is "late" what is the point here? It is NOT approved for MS. Low-Dose Naltrexone is NOT APPROVED AT ALL. Not 10 years not 20 years
2) LDN has been marketed on the internet. YES IT HAS. why argue this? Just because some quack like Bernard Bihari sells it to make big $$$ doesn't mean it is "marketed for MS". Marketed means ADVERTISED. It is advertised on the internet. Also: Bernard Bihari is not an MS neurologist he is a PSYCHIATRIST and what he is doing in my opinion is malpractice.
3) LDN does not work "differently" than high dose naltrexone. In fact nobody has looked at it because it is NOT APPROVED BY THE FDA in that dose. So claiming some kind of way it works differently is a misunderstanding of science. If it works differently then they should publish a paper on how differently it works. There is no data at all, and that is the truth
4) The "dose" should be determined in a clinical dosing trial. This has never been done. Instead we determine the dose from some psychiatrist who randomly determined it in what looks like trying to give a lower dose to avoid any real effect he can be sued over rather than a dose that is effective. What if low dose means low effectiveness? how about NO dose Naltrexone?
5) THERE ARE NO PUBLISHED REPORTS demonstrating effectiveness of LDN as of the date of this article by the NMSS (even the Crohn's trial was not finished and therefore NOT PUBLISHED). Someone at ThisIsMS needs to learn how to read. The example cited is NOT A TRIAL!!!! it is a laboratory study in test tubes, not people and not a trial. Presently there are two tiny pilot studies in Crohn's and IBS and NOT MS. The pilot studies found no effect of LDN, but rather looked at side effects and safety
6) ThisIsMS' EXAMPLE OF A "TRIAL" in LDN is laughable. It is not a trial, it is a laboratory experiment on a tumor in a petrie dish. Duh.
7) In science we don't use the Merriam-Websters dictionary to determine ENHANCE. Enhance means to increase in science. That's why we don't have housewives respond to the National MS society. LDN claims it increases CD4+ t-cells in HIV patients (and Bihari evidently gives this to the unfortuante AIDS patients in his care). RAISING CD4+ t-cells is TERRIBLE for MS patients and exactly how MS damages your brain.
Immune suppression does better than reduce your MS 30%. ABCRs reduce by 30%. Tysabri reduces by 68%. Campath/Alemtizumab may be more. Don't forget we can only get to 100% improvement here...
The only "SLOPPY ILL-INFORMED ARTICLE" is the one written by ThisIsMS