Although this is a small trial on a very limited number of RR patients, it is noteworthy that the degree of improvement in enhancing lesions in this study was within the realm of what has been observed previously for the four approved treatments in much larger trials.
Paced auditory serial addition (PASAT) cognitive testing was also measured in the study.
PASAT cognitive testing scores were significantly improved in the RR group (p = 0.04), but not in the SP group.
Although there are only a few studies addressing the biological significance of PROG synthesis in the brain, the autocine/paracrine actions of locally synthesized PROG are likely to play an important role in the viability of neurons and in the formation of myelin sheaths……..PROG may exert its neuroprotective effects by regulating expression of specific genes in neurons and glial cells, which may become hormone sensitive after injury…..Local synthesis of PROG in the brain and the neuroprotective and promyelinating effects of this neurosteroid offer interesting therapeutic possibilities for the prevention and treatment of neurodegenerative diseases, for accelerating regenerative processes and for preserving cognitive functions during aging.
Rita wrote:I have a question in mind from long time ago, how is possible to a pregnant woman recover (during this period) most of her problems caused by MS if these problems are derived by a destruction in the myelin sheet? It has no big sense; if there is a hole, there is and how could it disappear? Is the sheet remielyneted during a short period and returned to the old status in few days?
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