finn wrote:That was written almost 6 years ago, and still drug companies are developing drugs that are only able to "dampen down the hostile immune system", not halt the axonal damage. That is of course understandable, they just offer what the market wants. In my opinion the problem is that the majority of the MS community seems to be satisfied with the situation. Antegren will come, and everybody is happy. Our MRIs will look even better than with ABCRs!
If you use one of the ABCRs and you're not doing that fine, your neuro says you would do worse if you didn't use the drug. And if you use one of them and you're fine, it is only because of the drug you use.
It is worth of 14.000 euros a year, isn't it?
In MS, a number of events occur including inflammation, damage to myelin...and nerve fibre loss. The link between these processes is not fully understood although it's known that substantial inflammation is associated with a greater number of damaged nerve fibres. The purpose of this study was to assess whether widespread nerve fibre loss (a process called atropy) occurs, even when areas of inflammation in the brain and spinal cord (as visualised by MRI) have been suppressed.
.....Results showed that despite effective inflammation suppression, atrophy continued. The authors suggest that atrophy is likely to be triggered by a large amount of inflammation but proceeds independently even without continued inflammation.
Anonymous wrote:Seems to me that one approach to the question of drugs not getting trials is to work for an organization that would do independent trials on drugs overlooked by the existing system. Most of the trials would show no proof of efficacy, but I suspect every now and then a new treatment would be found and not just for MS but for a lot of things.
Yes, ideally this is one possible route to go but again it comes down to money ... who is going to fund it?
There is a MS medical group called the Consortium and they are looking at possibly doing some small trials for LDN.
And in Europe where social medicine is practiced far more, something like this has more of a chance of happening.
Unfortunately, the NMSS's press release on LDN would have scared a lot of people away, especially in the field of medicine. The NMSS carries a lot of weight when it comes to MS information and most medical people take what they say as gospel.
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