HarryZ wrote:not one treatment that has ever worked in that poor mouse has ever worked in a human.
Depends on what you call "worked." There's no cure, but there is solid evidence to indicate that the ABCRs delay the progression of MS in a significant percentage of the patients who take them. In any case, what's the alternative to the EAE model?
I think the problem of MS research goes way beyond the mouse. It is a fixation that researchers have had for decades that MS is solely an auto-immune disease and pretty much all research until a couple of years ago has been "locked" into this area. Even dare to suggest that this theory is wrong and other drugs have a more beneficial result will bring down the wrath on you by most MS docs and certainly the NMSS.
What "wrath" are you speaking of? Everywhere I look I see suggestions that MS might be more than one disease and that it might be caused or enhanced by viral infections. Seems to me that if someone has a different hypothesis they ought to get to work testing it and coming up with approaches based on their set of guesses. Proof's in the pudding.
Drs. Barnett and Prineas published their work in the Annals of Neurology regarding their findings in autopsies done on brain lesions of MS patients. They found no evidence of the immune system causing the damage. So far, the silence within the MS research world has been incredible. The boat is being rocked and I guess it will be a mater of time to see whether it tips over or continues along the same course.
What, you expect one article to change everyone's beliefs?
It these companies were producing drugs for another disease and had this kind of efficacy rate, they would likely have been out of business a long time ago.
You mean like the companies that make drugs for cancer that people keep dying of anyway, or the companies that make drugs for AIDS that people keep dying of anyway? Good God, Harry, you need to get used to the fact that at the present time MS is incurable. We'd all like it to change, but it has not changed yet. There are all kinds of incurable diseases out there that are treated with drugs that kinda sorta work. Grow up!
But they are producing them for MS and the CRABs are the only FDA approved drugs on the market. There is a $4 billion world wide market so you only need to do the math and figure out just how much money they are making. And Betaseron and Avonex enjoyed orphan drug status along the way so that helped their profits as well.
Yup, the ABCRs have orphan status. As would any other drugs for MS. There's still lots of dough to be made, wouldn't you say, Harry?
So, as long as the money continues to role in and the docs continue to prescribe the CRABs, everyone continues to follow the course.
That's ridiculous, given that a non-ABCR treatment for MS would also enjoy orphan drug status.
A few years ago a large MS clinic on the west cost of the US got $400.00 for every Betaseron prescription that they issued! Add the support from the docs and you can see how this "money machine" continues to stay in power.
Hey, and I bet the drug companies are putting MS germs in the water. Poisoning our precious bodily fluids, huh Harry?