Depends on what you call "worked." There's no cure, but there is solid evidence to indicate that the ABCRs delay the progression of MS in a significant percentage of the patients who take them. In any case, what's the alternative to the EAE model?.
I would think that after reading the many messages in this thread about the effectives of the CRABs and the serious doubts expressed about them by some MS researchers and the fact that only about 1/3 of the users get about a 1/3 reduction in exacerbations (close to placebo effect), I doubt one could say that the CRABs can be considered to "work" in MS. Add the side effects and cost and you get what Dr. Behan is saying....the CRABs are based on bad science and a lot of wishful thinking.
The alternative to that poor mouse is to start looking in areas that are not autoimmune related. I once read what one doctor called the definition of the word "stupid" when it comes to MS research...."doing the same thing over and over again and hoping for a different result". Sort of what the world of MS research has been stuck in for many years.
What "wrath" are you speaking of? Everywhere I look I see suggestions that MS might be more than one disease and that it might be caused or enhanced by viral infections. Seems to me that if someone has a different hypothesis they ought to get to work testing it and coming up with approaches based on their set of guesses. Proof's in the pudding.
You just have to read Dr. Bowling's comment on LDN done through the NMSS and the "MS adviser" to the UK MS Society to get an idea of how some of these docs respond to alternative theories. It's not a matter of saying that clinical trials haven't been done to prove these other drugs will work but they take it a step further and immediately condemn them as going against the current MS theory.(still unproven BTW)
If you look at the overall concern about LDN users it's the fact that they want clinical trials done for the drug but when you get replies from some docs through the NMSS like the ones that have been issued, it becomes very difficult for this to happen. Reading from another message, the NMSS controls about 75% of the MS world and when they make those statements, it has a huge impact.
What, you expect one article to change everyone's beliefs?
Not at all...but perhaps what these two very reputable MS researchers uncovered might start to change the thinking patterns of the established MS medical world. I suspect that the possibility that they may be right would cost a lot of people a lot of money.
You mean like the companies that make drugs for cancer that people keep dying of anyway, or the companies that make drugs for AIDS that people keep dying of anyway? Good God, Harry, you need to get used to the fact that at the present time MS is incurable. We'd all like it to change, but it has not changed yet. There are all kinds of incurable diseases out there that are treated with drugs that kinda sorta work. Grow up!
At least the cancer drug companies look in other directions when their drug fails on cancer or AIDS. Look at Betaseron...didn't work in cancer, didn't work in AIDS so they gave it to MS patients!!!
Now Willy, could I take the "grow up" comment as being a personal attack on me....something you whined about earlier? Maybe I should consider reporting you to Arron!
Yup, the ABCRs have orphan status. As would any other drugs for MS. There's still lots of dough to be made, wouldn't you say, Harry?
Just ask the NMSS and the ABCR drug companies....and don't anyone dare question or challenge their domain.
That's ridiculous, given that a non-ABCR treatment for MS would also enjoy orphan drug status.
One has to apply for orphan drug status..it doesn't come automatically and it isn't easy to get.
Hey, and I bet the drug companies are putting MS germs in the water. Poisoning our precious bodily fluids, huh Harry?
With comments like that, Willy, it's quite apparent your focus of attention is to try and ridicule me. I think the other readers in this discussion see right through your shallow comments and intentions. I really don't have to add much else...you are doing that all by yourself!