T3

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T3

Postby LR1234 » Thu Jun 10, 2010 10:34 am

Hi Anyone taken T3 to help with their MS?
I was speaking to a lady the other day who takes it, I then found this on the internet....

Blood levels of selected hormones in patients with multiple sclerosis.

Zych-Twardowska E, Wajgt A.

1st Chair and Department of Neurology, Silesian Medical University in Katowice, Poland.
Abstract

BACKGROUND: Hormonal studies in patients with multiple sclerosis are rare and they often produce results which are difficult to interpret. These investigations, however, are becoming more and more important as they may cast some light on possible interrelationships between hormonal and immune systems. The aim of the present work was to investigate endocrine function in patients with multiple sclerosis on the basis of blood levels of selected pituitary (TSH, ACTH, GH) and thyroid hormones (T3, T4), and cortisol. MATERIAL AND METHODS: Forty-nine MS subjects, including 25 menstruating women, 6 post-menopausal women and 18 men were included in the analysis. The hormones were measured by radioimmunoassay and immunoradiometric assay kids. RESULTS: Pituitary function in respect of TSH, corticotropin and growth hormone secretion was normal. Both men and women suffering from multiple sclerosis manifested low serum T3 concentrations coexisting with normal T4 levels which may indicate changed peripheral conversion pathway of thyroid hormones. On the other hand, the disturbances in pituitary-adrenal cortex system in respect of glycocorticosteroid secretion were not observed. CONCLUSIONS: Normal function in respect to pituitary hormones (TSH, corticotropin, growth hormone) and normal T4 level versus low serum T3 concentration may indicate changes in peripheral conversion pathway of thyroid hormones in MS patients.
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Postby shye » Thu Jun 10, 2010 5:54 pm

I was taking synthroid, and didn't help at all. then took synthroid and
T3--and ended up with too much t3--now use thyroid extract, and works okay.
Thyroid extract is natural hormone, with 38 mcg t4 and 9 mcg t3 per grain--(for some this is too much t3 apparently--for me is fine).

I always figured it was my damaged liver that just could not convert the t4 to t3--but in light of this info, could be combo of liver and MS--ie, needed more t3 than the norm because of the MS.
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Postby LR1234 » Fri Jun 11, 2010 2:32 am

Thanks for the reply Shye.
I started taking 50mcg of T4 (I had very high antibodies to my thyroid but my FT4 was in the normal range at the bottom of the scale) Then I started taking LDN and all my thyroid antibodies disappeared! So I stopped taking thyroxine. I have decided to go back on it 25mcg and maybe take 10mcg of T3 with it. What do you reckon? I have ordered Cytomel online (which is 20mcg so I will cut it in half)


Are you still doing chelation therapy? Has it been helpful? I am still thinking of having EDTA soon.

L x
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Postby shye » Fri Jun 11, 2010 5:44 am

HI LRi234
Be careful with the cytomel--T3 is extremely powerful--I started with 5 mcg, then we upped it too quickly to 25mcg, and ended up with hyper symptoms, hair loss, nerves a mess--so go very slowly--I'd start with 5--note the ratio that is in the natural thyroid--38 t4 to 9 t3--
maybe use tht ratio?

Yes I am still with the Chelation--but ran into high blood pressure issues, so had to stop for a bit til got that regulated--meant to post on the chelation thread, but am caught up in the Phlebotlomy angle now, and the chelation seem minor!! But will do chelation again today.
Can't say notice physically any difference yet with the chelation--need to get the tests done, and xray of neck, to see if the calcium deposits are decreasing. I do feel okay generally, yet still the incredible super fatigue hangs on. But will definitely continue with the chelation.

But was diagnosed recently with mutation in HH (Hemochromatosis) gene--heterozygous mutation of H63D gene
and had first phlebotomy two days ago--MAJOR difference--much less fatigue, brain fog seems gone, feel lighter ete etc
Check the "Phlebotomy Anyone" thread if want to follow this angle. Is very exciting. See my dr this AM, hope she will agree to weekly phlebs for a while (til get ferritin level down to at least 30). I will continue to post on the phleb thread.
and hope to soon get that post done on the chelation thread--think i will wait to do that til get some results on paper.
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Postby shye » Fri Jun 11, 2010 6:01 am

LR1234
Just clicked that you wrote that the thyroid antibodied disappeared--amazing--I got the LDN script filled, but with all the probs with high blood pressure, and now starting the Phlebotomy as well as continuing the Chelation, decided to hold off on the LDN for the time being.
So if the antibodies disappeared, what are you lab test results for TSH, T3 and t4?
Thyroid is not something to experiment with, I found out! At least get the lab results before doing anything. You can't just take t3 because it gives you energy--your lack of energy (if tht is the problem) is probably related in some other way to the MS. As I am finding, seems to definitely be related to iron overload.
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Postby LR1234 » Fri Jun 11, 2010 6:21 am

Thanks for the advice Shye. Yes, if LDN has done nothing else it def got rid of the TPO antibodies!!! SO LDN really does have some effect on antibodies.

So maybe I will do 25mcg of thyroxine and 5mcg of T3 to keep the ratio???
These seem very low levels so nothing dramatic should happen.

When tested originally my T4 was 8 (7.5-22) then when I took 50mcg of thyroxine my FT4 went to 23 (7.5-22) but the dr said that was fine.
My TSH though did lower than normal and still is like that hence me now stopping the thyroxine.

I will go back on 25mcg today and then get my bloods tested in a week or 2's time and hopefully I will be in the middle of the range.

I also have to get my lupus anticoagulant levels checked as when I was dx (pre-LDN) I had + antibodies and then I got tested again 6 weeks later and they became equivical which tells me that during the relapse that got me Dx my blood must have been thicker due to the antibodies.
I will get these checked at the same time as the thyroid.

Great news about the Iron!! My iron levels have never been abnormal however my serum iron levels were right at the top of normal during a relapse and then they went back down so something is going on with the iron. I might get my HH genes checked to see if I am a carrier just out of interest!
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Postby shye » Fri Jun 11, 2010 3:06 pm

I would get the tsh, t4 and t3 tested first, before going back on---in light of last TSH level. mcg's seem minute to us, but to the thyroid, they are huge amts 8O
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