My symptoms are at their mildest in the evening. This is also the time of day that I am least stressed, least busy, most relaxed, and least over-heated. The only symptom that was ever a problem at night after going to bed was lower-leg spasticity (this hardly ever happens now after the CCSVI treatment last September).
I've noticed the same thing about being on vacation (away from house chores and responsibilities, I no longer work). I still need rest breaks when I'm away, and I easily get overwhelmed if there is too much going on around me, but, in general, fatigue and cognitive-fog trouble me less when I am away from the home-routine in a restful location.
This wasn't true when I was still working. Body fatigue and lower-leg weakness were very unpleasant in the evening, after a full day's work.
CCSVI Procedure 9/16/2009 at Stanford
Stent in left and right IJVs
Copaxone and Ampyra user
Botox Bladder Injections