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Early diffuse demyelinating lesion in the cervical spinal cord predicts a worse prognosis in relapsing-remitting MS



Abstract
Objective: To study the long-term outcome and persistence of two patterns of cervical spinal cord abnormality in early relapsing-remitting multiple sclerosis (RRMS).
Methods: RRMS
patients with a spinal cord MRI performed during the first 3 years of the disease, a control MRI 5 years later and who have been followed up at least 10 years were included. Patients were grouped according the T2 spinal cord MRI into: (A) nodular pattern, if one or more focal lesions were present; and (B) diffuse pattern, defined as a poorly demarcated high signal area. The end point was defined as the time to reach an Expanded Disability Status Score (EDSS) of 4.0.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/2468

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