Harry / Finn,
I agree with Harry about EAE. Unfortunately, much of the research is still focussed on EAE. I often read the applications for research funding and they always state that they will test possible findings in a well known model of MS. I always sigh when I see this. I wonder how many PhDs have been earned from research involving EAE which has never benefitted any human with MS?
The odd thing is that they must now have a good idea that EAE is not a good model of MS. But changing the mindset of these people is an almost impossible task. Surely they can move on from this model!
In the UK, there is a tissue bank (MS tissue and normal tissue) and high powered MRIs dedicated to MS research etc etc. I assume this is replicated in many of the countries with high incidence of MS. When you add the information from autopsies, all the data from trials, natural history data of MS etc etc, it's almost scandalous that so little is actually known about this disease and that the researchers persist with the old models and the old theories. I would love to be a fly on the wall of one of the top MS researchers who arrives back home in the evening. What does he (or she) say when his wife (or husband) says 'had a good day at work dear'? What do they insert in their annual performance report - 'looked through a microscope for most of the year but didn't find anything'?
I know they will say that this is a very complex disease etc etc but their the ones with the title of specialist or expert.
In recent weeks there has been a dearth of MS research papers published. Not sure if some really big news is on the way? Probably not, but we all live in hope.
PS I attach a link to the latest NMSS research summary (it says for summer / fall 2005?). It's pretty thin and one of the items is myelin repair. The latter seems to be based on the belief that the immune system causes the damage to myelin, rather than a possible alternative theory that nerve degeneration is taking place which affects the myelin and then the immune system gets inolved. Again mice are being made to suffer.
http://www.nationalmssociety.org/Progre ... search.asp