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Tetanus immunization helpful for those with MS?

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Tetanus immunization helpful for those with MS?

Postby dignan » Tue Jul 19, 2005 12:12 pm

I guess this relationship still needs to be tested, but it's an interesting possibility.



Immunity to tetanus is protective against the development of multiple sclerosis

Verstraeten T, Davis R, Destefano F.
Epidemic Intelligence Service (EIS) Program, Epidemiology Program Office, Centers for Disease Control and Prevention, Altanta, GA, USA.


Following allegations that Hepatitis B vaccination causes or triggers multiple sclerosis (MS), several epidemiological studies have been conducted to evaluate the association between MS and vaccination.

In one study conducted in the US, a significant protective effect on the development of MS was observed for tetanus immunization. We reviewed the medical literature and found two additional recent studies, as well as several older studies, which also observed a significant protective effect of tetanus immunization on the development or progression of MS. Furthermore, decreased humoral and cellular immunity to tetanus toxoid has been observed among MS patients.

We postulate that naturally acquired or vaccine-induced immunity to tetanus has a protective effect against the development and progression of MS. We also postulate that this link to tetanus is in part responsible for the gender, age, geographic and socio-economic distribution of MS, as well as its pattern among migrants. The biological basis for this protective effect could be an unspecific boost of bystander suppression of auto-immunity as shown for other infections.

Our hypothesis can be tested in several ways. The simplest approach would be to compare tetanus exposure and MS occurrence on a population level. Stronger support would come from the re-analysis of previous studies that have information at the individual level on both tetanus exposure, whether induced or natural, and on the development of MS. Laboratory evidence could be sought by testing the effect of tetanus toxoid on experimental allergic encephalomyelitis, the experimental animal model of MS.

http://www.ncbi.nlm.nih.gov/entrez/quer ... query_hl=4
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Postby kareng7 » Wed Jul 20, 2005 2:51 pm

That would help explain why some MSers are finding it helpful to go on antibiotic therapy. Fascinating...
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Postby SarahLonglands » Thu Jul 21, 2005 11:25 am

Hang on a minute Kareng7, aren't you getting two things muddled up here? Namely bacterial and viral infections.

My antibiotic therapy was way more than merely helpful. It was also way more than a protective therapy: it completely rid me of the disease in the way these various chemotherapies are supposed to.
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Postby Toyoterry » Thu Jul 21, 2005 8:08 pm

I'm pretty sure tetanus is a bacteria, isn't it?
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Postby SarahLonglands » Fri Jul 22, 2005 12:15 am

Of course you are correct, but I must have been thinking more about hepatitis b, mentioned in the same post! :oops:
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Postby kareng7 » Fri Jul 29, 2005 6:44 pm

Anecdote wrote:Of course you are correct, but I must have been thinking more about hepatitis b, mentioned in the same post! :oops:


You had me wondering there for a moment. There is some confusion online when you do searches but tetanus is a bacterial infection, not viral.
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