DenverCO wrote:I just read better2gether's post in the Tysabri forum about the Sentinal results (Avonex/Tysabri combo). I've always wondered...
There were 1171 Avonex treated patients spread out over 123 trial sites. If it was a double blind study, does that mean there were double that number of actual participants? Why do they spread it out over such a large number of sites? Wouldn't 50 or so sites provide a representative sample and greatly reduce costs?
HarryZ wrote:"Double blind" in trials refers to the fact that both the doctors and patients do not know who is taking the drug or getting the placebo. Only when the trial ends do they break the code and know who was actually on the drug. It has no bearing on the number of patients in the trials.
Harry, I know what a double blind study is, but can we assume that there is one person receiving the placebo for every person receiving the actual drug? If that is the case then when they report that a study revealed that 500 patients receiving a new drug experienced certain results, can we assume that there were 1000 participants (500 who got the drug and 500 who got the placebo)?
I'm not asking for any particular reason, just curious.
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