I believe that at a young age when the thymus is producing naive white blood cells, paired with a horrible diet and low vitamin D, there is a situation where the fat that makes the blood brain barrier (BBB) is brittle and contains many of the precursors of bad-prostaglandins. When the BBB is assaulted by any foreign element, especially a retrovirus like Epstein Barr, it over reacts. (Epstein Barr is incredibly interesting in its effects on the BBB and vasodilation as it travels back and forth across the BBB). This causes a cascade of inflammation which signals white blood cells to arrive. Since these are naive white blood cells, they are still becoming sensitized to foreign elements. Once they pass the BBB to fight off the foreign invader, they tend to stay busy if they cant find any thing else to fight. Well, they are not supposed to be in the CNS and can't get out as easy as they came, so the myelin sheath seems more and more foreign looking and they begin treating it like a virus and going to work. Then they become sensitized to the CNS myelin. Congratulations, ten years down the road you have MS. I guess the best bet is keeping the little buggers out of the CNS.
MSBOB wrote:J Neuroimmunol. 2011 Jan;230(1-2):173-7. Epub 2010 Sep 9.
Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis.
Casiraghi C, Dorovini-Zis K, Horwitz MS.
Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.
Multiple sclerosis (MS) is an inflammatory neurological disease that is widely regarded as the outcome of complex interactions between a genetic predisposition and an environmental trigger. Epstein-Barr virus (EBV) has recently been associated with the onset of MS, yet understanding how it elicits autoimmunity remains elusive. Neuroinflammation, including the entry of autoreactive T cells, likely follows a breach of the blood-brain barrier (BBB) leading to CNS lesions in MS. We show that EBV can infect human BBB cells leading to increased production of pro-inflammatory mediators that result in immune cell adherence thus modeling a key step in MS pathogenesis.
Copyright © 2010 Elsevier B.V. All rights reserved.
LR1234 wrote:So how do we get rid of epstein barr or at least take something to inactivate it.
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