Six years ago we had a discussion about the polyamine hypothesis I have been developing. Since then I have kept relatively quiet about it here but I continued working on it. I have developed it a lot further, but it is still centered around the same concepts as were discussed.
Last year I presented it very briefly in Brest, France at a Sjogren's syndrome symposium. (I have been fortunate to write some articles with some really good French autoimmune researchers recently.)
I guess there was some interest in the hypothesis because I was invited to Zurich to present it before some of the big names in autoimmune research. I presented it last week (Saturday) and I think it went fairly well, inspite of only about 12 hours sleep the 5 days before, and about 12 hours since. (I have a real problem with jetlag. I don't get nervous about talks, just get insominia practicing my talk as I try to fall asleep.) I got some very positive comments afterwards and unofficial invites to present it to other groups. Actually I only presented the core, about half of the hypothesis, since I am in the process of writing some new additions to it. And, after this recent talk, I have ideas for several more additions. Perhaps when I get things published, I can do an update on the hypothesis for TIMS.
Epigenetics and autoimmunity is really a hot topic this year. I hope to present the hypothesis on more occasions during the next year if given the opportunity. I can't afford much travel (money and time wise) so I will have to be selective.
Anyway, presenting the ideas six years ago and getting questions from TIMS members encouraged me and helped me improve the hypothesis. Thanks for your help. We're not done yet.