They could be on to something

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Postby rainer » Tue Apr 08, 2008 3:46 pm

good to see another possible avenue for treatment but frustrating to see you were posting this in 2005 :?
User avatar
rainer
Family Elder
 
Posts: 367
Joined: Thu Jan 17, 2008 4:00 pm

Postby dignan » Tue Apr 08, 2008 7:36 pm

I agree, it is a bit frustrating, and the UC Irvine group isn't even at the IND stage, they're still doing pre-clinical work. One company that is working on the same target is Bionomics. They still haven't even selected their drug candidate yet, although if you believe their material, they are due to pick their candidate any day now.
User avatar
dignan
Family Elder
 
Posts: 1608
Joined: Wed Aug 11, 2004 3:00 pm

Postby gibbledygook » Fri Apr 11, 2008 9:33 am

Genistein inhibits kv1.3 (give up milk and eat soy!).
<shortened url>
Red wine
<shortened url>
Zinc
<shortened url>

looks like green tea and curcumin inhibit potassium channels with different numbers...
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
User avatar
gibbledygook
Family Elder
 
Posts: 1412
Joined: Mon Feb 14, 2005 4:00 pm
Location: London

Postby dignan » Mon Apr 21, 2008 9:20 pm

Gibbledygook, thanks for the info. I'm always interested in excuses for drinking more red wine, and I already use soy milk...now to go read some of jimmylegs' rantings about zinc...

I also found this on Kv1.3


Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression.

J Neurochem. 2007 Dec;103(5):2035-46. Epub 2007 Sep 14.
Nutile-McMenemy N, Elfenbein A, Deleo JA.
Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Minocycline is a semisynthetic, tetracycline derivative that exerts anti-inflammatory and neuroprotective effects unrelated to its anti-microbial action. We have previously shown that minocycline prevented peripheral nerve injury-induced mechanical allodynia. Minocycline's mechanisms of action as a neuroprotective and anti-allodynic agent are unknown.

In response to injury, microglia become activated, proliferate, and migrate. Resting microglia express voltage-dependent inward K(+) currents and blocking Kv1.3 channels has been shown to inhibit microglial-mediated neuronal death. We investigated the effect of minocycline on the expression of Kv channels, cell motility, and beta-integrin expression using primary rat cortical microglia, transwell assays, and by flow cytometry.

Minocycline significantly reduced microglial migration to cellular debris, astrocyte-conditioned medium, ADP, and algesic mediators and significantly reduced the expression of CD29 (beta(1)-integrin) but not CD18 (beta(2)-integrin). Minocycline reduced the effect of extracellular potassium and later decreased microglial Kv1.3 expression. In summary, we uncovered a novel effect of minocycline that demonstrates this agent decreases microglial beta(1)-integrin expression, which leads to inhibition of motility. We propose an in vivo model whereby reduced microglial trafficking to injured neurons following nerve injury decreases the release of proinflammatory mediators into the synaptic milieu, preventing neuronal sensitization, the pathological correlate to chronic pain.

Pubmed link
User avatar
dignan
Family Elder
 
Posts: 1608
Joined: Wed Aug 11, 2004 3:00 pm

Previous

Return to General Discussion

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service