they want to hold a clinical trial and are in the process of finding something to test.
K+ channel blockade by progesterone is specific; other steroid hormones had little or no effect,…..
Progesterone effectively blocked a broad spectrum of K+ channels, reducing both Kv1.3….
We propose that direct inhibition of K+ channels in T cells by progesterone contributes to progesterone-induced immunosuppression.
Thiamine deficiency (TD) in both humans and experimental animals results in severe compromise of mitochondrial function and leads to selective neuronal cell death in diencephalic and cerebellar structures.
Neurodegenerative diseases are characterized by abnormalities in oxidative processes, region-selective neuron loss, and diminished thiamine-dependent enzymes. Thiamine deficiency (TD) diminishes thiamine dependent enzymes, alters mitochondrial function, impairs oxidative metabolism, and causes selective neuronal death…..
We examined the effects of thiamine and its derivatives on voltage-gated ion channels of neuronal cells ….
These results suggest that phosphorylated thiamine can function as an endogenous K+ channel blocker in neuronal cells.
Forms of the vitamin
Thiamin is found in most animal tissues predominantly in phosphorylated forms (e.g., thiamin mono-, di- and tri-phosphates). ... thiamin is found in the diet in one of three forms: free thiamin, phosphorylated thiamin, and protein-phosphate complexes.
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