Ian--good to see you posting and hope you're doing well. Sorry the thread was locked but glad Dignan started it again.
Welcome back to old times.
Some things don't change.
Hormones are still looking good for myelination/remyelination.
A few more recent tidbits.
17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice
These data show that sex steroids can protect the brain from demyelination and stimulate remyelination..... The positive hormonal influence on myelination in the CNS may be a future therapeutically strategy for the treatment of MS.Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination
These findings show a direct neuroprotective effect of oestrogen receptor β ligand treatment on oligodendrocyte differentiation, myelination and axon conduction during experimental autoimmune encephalomyelitis.
Previously my focus had been just on progesterone and myelination
, but now estrogen has come into the picture too.
Quoting from the BBC article Ian posted:
Around 85% have the relapsing/remitting form of the condition, in which "flare-ups" which cause disability, are followed by a recovery of a level of the lost physical function.
In this form of MS, there does appear to be some natural myelin repair
I still wonder why there's not been a focus on declining hormone levels with age and whether or not those declining hormone levels contribute to the failure to remyelinate as time and MS march on. I still think it's entirely possible that's a major factor in our eventual apparent inability to remyelinate.
Of course, we do have to stop the demyelination process (and some others IMO) too......
Take care and all the best.