tzootsi wrote:Leonard wrote:tzootsi wrote:A promising spin off of CO-Q-10 is idebenone, which is supposedly a much more potent CO-Q-10 synthesys. It's actually in trials for PPMS.
whow amazing, any references there?
http://clinicaltrials.gov/ct2/show/NCT0 ... 248&rank=1
Idebenone is available at several on line vitamin shops.
Zinc and taurine were measured in urine in the fasting state and following a 4mg/kg load of taurine in subjects with Friedreich's Ataxia (FA), and healthy controls (C), and subjects with Duchenne type muscular dystrophy (MD). Of the FA, 25% had increased fasting excretion of zinc, and 50% had increased excretion of zinc following the taurine load. ... As an index of zinc deficiency, uptake of zinc by erythrocytes was measured in all subjects and in heterozygotes for FA. The pattern of uptake was abnormal for FA and heterozygotes. Hair analysis for zinc showed that 10 of the 12 FA subjects had low values
...Excess zinc in the growth medium also influenced the phenotypes of yfh1 cells. It prevented the accumulation of iron in the mitochondria of yfh1 cells and increased the growth rate of these cells and their resistance to oxidative stress. However, zinc did not restore the deficiency of Fe–S and haem proteins of yfh1 cells. Zinc inhibited mitochondrial respiration and protected Yah1p, the mitochondrial ferredoxin. These results suggest that zinc nutrition may be important in the aetiology of Friedreich’s ataxia
gainsbourg wrote:I agree that zinc is of paramount importance in MS bcause it is so often deficient - even though very likely your neurolgist will never so much as mention the word zinc.
Friedreich’s is caused by an iron accumulation in the mitochondria of nerve cells due to a rare genetic flaw which causes faulty iron metabolism. I have been convinced for a while that incorrect iron metabolism is also happening in MS and is the likely cause of the mystery iron deposits.
Of course MS could be causing the faulty iron metabolism rather than the other way round. This argument can also be used to counter any theory of MS that points at metabolism.
High doses of zinc will tend to reduce the absorption of iron (magnesium, Vitamin B2 and E are also iron antagonists)
is there anything we could do to normalise the (iron) situation?
gainsbourg wrote:Bear in mind that both herpes outbreaks and MS attacks have strong associations with stress. Mine is an unusual theory I know! But then your theory, Leonard, isn't exactly orthodox!
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