Let's just assume that micro-cellular nutrition is the problem in MS. Let’s also assume as well that in addition to a local problem (close to the narrowings of the neck veins) there can also develop a global problem (a whole body problem of poor GLUT translocation, insulin resistance). In fact, the double peak in the graph of the age of onset suggests two different underlying mechanisms are at work here.
People with MS have a high glucose demand; their cells are screaming for energy. Sugars and glucose are the easiest to get out of the bloodstream. Some people with MS have a high sugar consumption.
We know too much sugar is bad. On this thread, several publications may be found that argue that a prolonged use of sugar may be linked to increasing insulin resistance. Sugar gives a short boost but in the long run high sugar consumption does the opposite and you need to take ever more for the same effect. You get into a vicious circle.
In the newspaper and Internet today a new type of cholesterol is presented that is more dangerous than LDL, called MGmin-LDL. It's denser and stickier than LDL. Well, cholesterol (HDL / LDL) is not as bad as previously thought, but this particular version is. And this ultra bad cholesterol uses sugar to grow.
http://www.nursinginpractice.com/articl ... identified
and many other links can be found by Googling on MGmin-LDL.
The risk of cholesterol is always related to the narrowing of arteries where plaques reduce the passages and passages may get completely blocked. With catastrophic consequences. Of course it is. But once again I think conceptually we may looked at the issue broader. I think these sticky micro-structured plaques could also block the fine "pores" of veins and capillaries, closing them off for glucose and oxygen transport. Thus hindering the transport of micro-cellular nutrition! It is another way of looking at the effects of cholesterol, but potentially just as disastrous in particular if you already have poor or malnourished cells/neurons.
Metformin stimulates an enzyme that allows the GLUTs to work better, and thereby promotes cellular nutrition (and thus helps to overcome "insulin resistance"). Metformin is also said to have the ability to lower glucose levels. I think because glucose is better absorbed by the cells, and thus the level in the blood drops.
But an article in a local paper also suggests that Metformin helps to block the formation of the ultra bad cholesterol. Thus, Metformin could be a useful drug (fully apart from diabetes2) to keep open the fine "pores" in the vessel walls and thereby promote micro-cellular feeding.