This thread argues that an impaired glucose transport is the cause of MS. There are a number of remarkable features of MS that would seem to suggest such relation: the double peak in the graph of the age of onset of MS and the hardening/calcification of veins at mid age; the vitamin D relationship and intracellular calcium levels; the feeding of cells through the BBB only by glucose and the relation with the quality of the myelin in teh cerebro-spinal as opposed to other parts of the body; the prevalence of diabetes in MS.
The high consumption of sugar among MS patients is known. Also, the short term improvement of motor functions on the intake of sugar is known. But on the long term, this sugar intake may be devastating for the functioning of the endothelium (the inside of the vessel walls) and indeed the functioning of the BBB; and cause a further calcification of endothelial cells. This article from 2009 would seem to suggest such course:
I quote from the article: Collectively, these results suggest that endothelial cells may react in a biphasic way to HG conditions with a short-term exposure resulting in an enhanced Cai2+ response to Ca2+ mobilizing agents and an increase in NO generation while chronic exposure to HG impairs function. Reports that NO generation and blood flow increased and peripheral resistance decreased in the early stages of diabetes (32, 51) whereas long-term diabetes leads to macro- and microangiopathy with reduced vascular reactivity (3, 52) lend support to the concept of HG-induced time-dependent changes in endothelial function.
The devastating effects of sugar can be found on many websites, and include suggestions for the onset of neuro-inflammatory diseases as MS: http://answers.yahoo.com/question/index ... 105AAjkonM
http://www.mvholisticretreat.com/articl ... eet-poison
On the Dutch webforum, a reaction to my suggestion on the glucose link said: When I was diagnosed in 1995, my neurologist at the time (a man who was already in his 60's) told me to stop immediately with the consumption of sugar … according to him, this was very bad … Perhaps, there is some wisdom in his advice. And indeed, as has been suggested above in this thread, the high consumption of sugar, although giving some immediate alleviation, could well cause a vicious circle with a further calcification of the endothelial cells that would further impair glucose transport etc.
Many of these processes can go on long before any signs of diabetes type 2 show up in the form of high blood sugar and increased insulin resistance.
I have seen on www.ccsvi-tracking.com
that some patients get worse after liberation. My theory goes as follows: when liberated, the blood flow is much stronger, also the supply of glucose. Things like REM sleep and dreaming (high glucose demand) and some motor functions improve. But the same time, particularly for mid-age and older patients, the calcification of the endothelium may increase as a result of the improved blood flow and glucose content. With detrimental consequences on the longer term.
It would be very interesting so see the age of those people that report worsening of functions.
The advice to stop sugar intake should therefore be taken very serious. And perhaps things like Metformin that help glucose transport (and help stop further calcification?) should be studied as a matter of urgency.