The impact of parasite infections on the course of multiple

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The impact of parasite infections on the course of multiple

Postby ikulo » Tue Feb 01, 2011 1:47 pm

J Neuroimmunol. 2011 Jan 28. [Epub ahead of print]
The impact of parasite infections on the course of multiple sclerosis.

Correale J, Farez MF.
Abstract

Previously, we demonstrated that helminth-infected MS patients showed significantly lower number of relapses, reduced disability scores, and lower MRI activity compared to uninfected MS subjects. In the current study, 12 patients with diagnosis of relapsing remitting MS presenting parasite infections were prospectively followed during 90months; due to exacerbation of helminth-infection symptoms after 63months of follow-up, 4 patients received anti-parasite treatment. Helminth-infection control was associated with significant increase in clinical and radiological MS activities. Moreover, these patients showed significant increase in the number of IFN-γ and IL-12 producing cells, and a fall in the number of TGF-β and IL-10 secreting cells, as well as CD4+CD25+FoxP3+ Treg cells evident 3months after anti-helminth treatment began. These new observations on parasite infections associated to MS indicate that parasite regulation of host immunity can alter the course of MS.
Copyright © 2011 Elsevier B.V. All rights reserved.
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Re: The impact of parasite infections on the course of multi

Postby roadaction13 » Fri Feb 04, 2011 7:30 pm

Thank you for this information. I'm confused by the language - is this a good or a bad thing: "Helminth-infection control was associated with significant increase in clinical and radiological MS activities." Do they mean that controlling the infection - i.e. giving anti-parasite treatment to those 4 people - meant their MS got worse?

JD
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Re: The impact of parasite infections on the course of multi

Postby mrbarlow » Sat Feb 05, 2011 5:08 pm

roadaction13 wrote:Thank you for this information. I'm confused by the language - is this a good or a bad thing: "Helminth-infection control was associated with significant increase in clinical and radiological MS activities." Do they mean that controlling the infection - i.e. giving anti-parasite treatment to those 4 people - meant their MS got worse?

JD


Yes - where MS patients got de-wormed they tended to have more MS activity.
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Postby Lyon » Sat Feb 05, 2011 5:21 pm

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Postby roadaction13 » Sat Feb 05, 2011 5:22 pm

Do you know if there are any MS patients who have started helminth therapy while on tysabri?
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Postby Lyon » Sat Feb 05, 2011 5:31 pm

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Postby roadaction13 » Sat Feb 05, 2011 5:36 pm

yeah well that's the thing - I want off of tysabri - tested positive for JC virus, going in for infusion #7 or 8 next week...

but the wormsellers say that you should stay on your treatment and slowly reduce the dose over 3 months - which makes me think they havent' dealt much if at all with tysabri, though he said he thinks there's been 1 or 2 people...

but if I start while still under a year of infusions, i'm still not much in the danger zone of PML, and figure I could start spacing out the infusions - 4 weeks, then 6, then 8, then 12, then off, something like that?

not sure what to do - or if I'm going to throw down the cash for the worms - it is a chunk of change, whereas fortunately my insurance covers all but $1.60 of my tysabri infusion (!)

any other thoughts, advice appreciated.

JD
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Postby Lyon » Sat Feb 05, 2011 5:43 pm

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Postby roadaction13 » Sat Feb 05, 2011 5:50 pm

sure, everything helps!
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Postby Apuman » Sun Feb 06, 2011 1:38 pm

roadaction13 wrote:yeah well that's the thing - I want off of tysabri - tested positive for JC virus, going in for infusion #7 or 8 next week...

but the wormsellers say that you should stay on your treatment and slowly reduce the dose over 3 months - which makes me think they havent' dealt much if at all with tysabri, though he said he thinks there's been 1 or 2 people...

but if I start while still under a year of infusions, i'm still not much in the danger zone of PML, and figure I could start spacing out the infusions - 4 weeks, then 6, then 8, then 12, then off, something like that?

not sure what to do - or if I'm going to throw down the cash for the worms - it is a chunk of change, whereas fortunately my insurance covers all but $1.60 of my tysabri infusion (!)

any other thoughts, advice appreciated.

JD


Hi JD,

I'll start by telling you what I tell everyone considering helminthic therapy: You're going to be assuming a risk.

That's not say that there's any MS therapy with out risk. Being on Tysabri, you're obviously well aware of that fact. The difference with helminthic therapy is that the risks are less known. From the research I've done, it appears to be generally effective and safe in comparison, but there are still many unknowns. Reactions and complications from combining therapies is one of those unknowns.

As Bob pointed out, both regulate the immune system. As of yet, I haven't seen any information pertaining to helminthic therapy and the JC virus. Essentially, you would be sailing into uncharted waters. Your experience could turn out to be very valuable to the MS community at large, as well as very effective for you, I would hope.

It's great that you're working to educate yourself as much as you can before making your decision. For that reason, I trust you'll be able to choose wisely.
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Re: The impact of parasite infections on the course of multi

Postby NHE » Mon Feb 07, 2011 2:35 am

roadaction13 wrote:yeah well that's the thing - I want off of tysabri - tested positive for JC virus, going in for infusion #7 or 8 next week...

but the wormsellers say that you should stay on your treatment and slowly reduce the dose over 3 months - which makes me think they havent' dealt much if at all with tysabri, though he said he thinks there's been 1 or 2 people...

but if I start while still under a year of infusions, i'm still not much in the danger zone of PML, and figure I could start spacing out the infusions - 4 weeks, then 6, then 8, then 12, then off, something like that?

not sure what to do - or if I'm going to throw down the cash for the worms - it is a chunk of change, whereas fortunately my insurance covers all but $1.60 of my tysabri infusion (!)

any other thoughts, advice appreciated.

JD


Knowingly ingesting an infectious organism while on a strong immunosuppressant such as Tysabri sounds like a dangerous idea.

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Humira and helminthic therapy

Postby HelminthicTherapy » Mon Feb 07, 2011 5:56 am

I was on Humira for over a year for my severe Crohn's when I started using helminthic therapy: 35 hookworms and 2500 whipworms. I tolerated it just fine and within 6 months was able to stop Humira and other medications and lost all my Crohn's symptoms. This was a year ago and I am still in remission. From what I understand Tysabri and Humira are very similar.
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Re: Humira and helminthic therapy

Postby NHE » Mon Feb 07, 2011 7:04 am

HelminthicTherapy wrote:I was on Humira for over a year for my severe Crohn's when I started using helminthic therapy: 35 hookworms and 2500 whipworms. I tolerated it just fine and within 6 months was able to stop Humira and other medications and lost all my Crohn's symptoms. This was a year ago and I am still in remission. From what I understand Tysabri and Humira are very similar.


humira.com wrote:HUMIRA is a TNF-blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection.
  • Serious infections have happened in patients taking HUMIRA. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your doctor should test you for TB before starting HUMIRA, and monitor you closely for signs and symptoms of TB during treatment with HUMIRA. If your doctor feels you are at risk, you may be treated with medicine for TB.
  • Certain types of Cancer. There have been cases of unusual cancers in children and teenagers using TNF-blocker medicines. For children and adults taking TNF-blocker medicines, including HUMIRA, the chance of getting lymphoma or other cancers may increase. Some patients have developed non-melanoma skin cancer; tell your doctor if you have a bump or open sore that doesn’t heal.


In contrast, Tysabri blocks VCAM-1. This action prevents immune cells from crossing out of blood vessels into surrounding tissue.

Tysabri PI wrote:Natalizumab binds to the alpha4-subunit of alpha4beta1 and alpha4beta7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the alpha4-mediated adhesion of leukocytes to their counter-receptor(s). The receptors for the alpha4 family of integrins include vascular cell adhesion molecule-1 (VCAM-1), which is expressed on activated vascular endothelium, and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) present on vascular endothelial cells of the gastrointestinal tract. Disruption of these molecular interactions prevents transmigration of leukocytes across the endothelium into inflamed parenchymal tissue.
    ----------------------------------------------------------------------
The immune system effects of TYSABRI may increase the risk for infections. In Study MS1 [see Clinical Studies (14.1)], certain types of infections, including pneumonias and urinary tract infections (including serious cases), gastroenteritis, vaginal infections, tooth infections, tonsillitis, and herpes infections, occurred more often in TYSABRI-treated patients than in placebo-treated patients [see Warnings and Precautions (5.1), Adverse Reactions (6.1)]. One opportunistic infection, a cryptosporidial gastroenteritis with a prolonged course, was observed in a patient who received TYSABRI in Study MS1.


Both drugs suppress the immune system, but in different ways and both drugs increase the occurrence of infections.

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