but I've heard a number of stories that suggest that it can be a serious issue, such as severe relapses after going off medication or missing doses.
OBJECTIVES: To confirm that neutralizing antibodies (NAb) to interferon beta can persist after therapy withdrawal and to evaluate whether persisting NAb are associated with a worse clinical disease course in multiple sclerosis (MS).
CONCLUSION: Anti-interferon beta NAb can persist after interferon beta treatment withdrawal and are associated with overt clinical disease activity. This is made apparent by an increase in relapse rate and faster disability progression and is supported by the observed need for more aggressive therapy after interferon beta treatment cessation. Prospective studies are warranted to confirm these results.
Shayk wrote:I know nothing about interferon dependency, but I think all should be aware of the potential impact of neutralizing antibodies when on an interferon.
seeva wrote:HI Sheldon my name is seeva my friend and I stop using any interferon for the last 4years since we have started taking LOW DOSE NALTREOXEN CAPSULES.we didnot had any relapses since 1996. according my last MRI scan my nuro told me that my m.s is stable. DR.BOB LAWRENCE FROM U.K has e.mail to me that if you are on LDN you have to stop all interferon. that is why my friends and i stop any interferon injections. you can send a e. mail to DR. LAWRENCE on firstname.lastname@example.org he will adsvice to you what you can do when you are on LDN.
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