This Is MS Multiple Sclerosis Community: Knowledge & Support

I wanted to start a thread do discuss the possibility of PWMS becoming dependant on interferon medications. So far, I have seen very little official information on the subject, but I've heard a number of stories that suggest that it can be a serious issue, such as severe relapses after going off medication or missing doses.

I invite anyone to post with their experiences of missing doses, going off meds, symptoms that they noticed, relapses that happened, relapses that didn't happen, or any other relevant information you would like to add.

-Sheldon

I have missed doses a time or two....
That being said, I am on Rebif.
I feel now that if you miss a dose, then continue on with regular doses, your body will ley you know!
When I miss a dose, then pick back up on the next scheduled dose, I get FLU like symptoms severly for about a week.

_________________
w/m 44
The problem comes with the decision of weighing the unknown with the unknown.

Sheldon

You asked about interferon dependency and going off it.

I know nothing about interferon dependency, but I think all should be aware of the potential impact of neutralizing antibodies when on an interferon. Here's one study:

Clinical effect of neutralizing antibodies to interferon beta that persist long after cessation of therapy for multiple sclerosis

Hope that adds to your quest for more information.

Sharon

Thank you Sharon. Changes to body chemistry that persist after treatment is stopped, and have been shown to have negative effects on the course of the disease, I would definitely classify as dependency. It would seem to me that interferons have the potential to modify the disease course while treatment is continued, but they may simply be holding back a landslide.

I would also be curious as to how the neutralizing antibodies work to cause a negative disease course in the absence of the medication, but that would be another study all together.

HI Sheldon my name is seeva my friend and I stop using any interferon for the last 4years since we have started taking LOW DOSE NALTREOXEN CAPSULES.we didnot had any relapses since 1996. according my last MRI scan my nuro told me that my m.s is stable. DR.BOB LAWRENCE FROM U.K has e.mail to me that if you are on LDN you have to stop all interferon. that is why my friends and i stop any interferon injections. you can send a e. mail to DR. LAWRENCE on boblawrence@ntlworld.com he will adsvice to you what you can do when you are on LDN.
regards
seeva :roll:

Thank you Seeva, I'm happy to hear about your success with LDN! It would likely be my next step if my helminthic treatments were to prove themselves not to be effective.

I missed one dose last night but took it two hours ago.

I don't know about dependency but the shivers I get are beyond belief. Im in Saudi Arabia I have the oven on, heating, Im wrapped up in a duvet and still cold.

Worst affected are my feet and hands - like they have been plunged into ice.

Sorry Seeva, but Dr Lawrence is completely wrong about LDN and interferons. If you go to the LDN Trust, there is good evidence there as to why the two drugs are not counteracting each other.
There are a great many people taking LDN and interfeons together with excellent results.
Dr Lawrence's advice is old and out of date and with so many people taking interferons and LDN together, he should stop advising people wrongly.