Help - bladder issue advice really needed

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Postby jimmylegs » Sun Feb 27, 2011 2:49 pm

http://en.wikipedia.org/wiki/Vasopressin
Arginine vasopressin (AVP), also known as vasopressin, argipressin or antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals, including humans. It is derived from a preprohormone precursor that is synthesized in the hypothalamus...

http://en.wikipedia.org/wiki/Vasopressin_analogue
Vasopressin analogues are chemicals similar in function but not necessarily similar in structure to vasopressin (ADH), such as desmopressin.

http://en.wikipedia.org/wiki/Vasopressin
Vasopressin analogues... used therapeutically in various conditions, and its long-acting synthetic analogue desmopressin is used in conditions featuring low vasopressin secretion

on supporting the hypothalamus... some interesting article titles

"Centrally administered murine-leptin stimulates the hypothalamus-pituitary-adrenal axis through arginine-vasopressin"

"Human leptin levels are pulsatile and inversely related to pituitary-ardenal function"

"Role of leptin in hypothalamic–pituitary function"

how to increase leptin..

Zinc May Regulate Serum Leptin Concentrations in Humans
Zinc restriction decreased leptin levels while zinc supplementation of zinc-depleted subjects increased circulating leptin levels.
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Postby lyndacarol » Sun Feb 27, 2011 3:10 pm

Wonderfulworld – For what it's worth, I tend to agree with JL and others that the bladder problem is probably the result of spasms.

But, just in case you develop a UTI: in today's newspaper I read that the Romans used horseradish for medicinal purposes – for bronchitis, urinary tract infections, and sinus congestion.

Then, I remembered a tip from someone on The Dr. Oz Show in the last month. It was suggested that a person take 2 teaspoons of horseradish sauce daily for a UTI. I hate horseradish – I'm sure I could never do this!

Just sharing.
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Postby Wonderfulworld » Mon Feb 28, 2011 1:12 pm

Jimmylegs sorry I forgot to thank you for the informative Mg ref range info a few posts back! - thank you. And the 'pressin' /leptin/'zinc link is very interesting too. Will take an extra zn tonight :D Annoyingly I forgot to ask my GP to take my zn levels when I was there 2 weeks ago.

Good news is the Urodynamics clinic can see me tomorrow 8) so off I go to see what info they can give me, or prescription, depending on whether it's retention, frequency or UTI etc.
One thing they did say when talking to me today was that Solifenacin can take up to a MONTH to take effect properly! So if I do need to take it, I will need to give it longer than a week.

Lynda - horseradish - if it cures the bladder issue I'd eat a pot a day! - but I think the Urodynamics people will check me tomorrow for a UTI but interesting about the horseradish!
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RR-MS dx 1998 and Coeliac dx 2003
~~~~~~~~~~~~~~~
Copaxone, Cymbalta. EPO, Fish Oils, Vitamin D3 2000 IU daily, Cal/Mag/Zinc, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle.
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Postby jimmylegs » Mon Feb 28, 2011 2:33 pm

no probs ww! lol @ 'pressin' - no relation to cure's solution ;)
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Postby Wonderfulworld » Tue Mar 01, 2011 2:00 pm

UPDATE
just thought I'd update this for those reading with similar problems...went to urodynamics today - my bladder is functioning normally, no infection, no retention- although my problems occur at night so it's hard to replicate that at a daytime clinic. So it seems it is completely down to incorrect nerve signals telling me I need to void, when there is little or no urine there.

I was finding the catheter uncomfortable to use, but the nurse tried a smaller gauge and it was so easy to use, so that was a major plus.

I will give solifenacin a longer try-out as the nurse said a 1 week use wasn't long enough but she said to go back to my GP to ask to try the other drugs out there too if solifenacin really isisn't working.

Thanks for all your comments and help guys.
Hopefully this bladder-from-hell will give me some peace soon. :roll:

ETA:
no probs ww! lol @ 'pressin' - no relation to cure's solution Wink
Ah stop JL :lol: the solution is now pressin and jumpin............
~~~~~~~~~~~~~~~
Concussus Resurgo
~~~~~~~~~~~~~~~
RR-MS dx 1998 and Coeliac dx 2003
~~~~~~~~~~~~~~~
Copaxone, Cymbalta. EPO, Fish Oils, Vitamin D3 2000 IU daily, Cal/Mag/Zinc, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle.
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Postby jimmylegs » Tue Mar 01, 2011 2:31 pm

lol :)

don't forget what mag has to do with those nerve signals!
(pls forgive the random non-academic source but this stuff is throughly academically documented elsewhere here at TIMS)

http://blogs.cybersym.com/ultrarunning- ... ml?start=4

"The mechanism of neurotransmitter release typically involves ... membrane rearrangement that has very specific requirements for concentrations of sodium, calcium, and magnesium ions on the inside and outside of the neuronal cell membrane. For example, when magnesium is insufficient at the junction between a motor neuron and a muscle cell, the junction (and therefore the target muscle cell) is hyperexcitable."
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Postby lyndacarol » Thu Aug 04, 2011 6:50 pm

WonderfulWorld – Did your urologist ever prescribed Botox? Here is a recent article about coming approval in the US:

http://www.reuters.com/article/2011/08/ ... 1J20110803

You wrote, "it seems it is completely down to incorrect nerve signals telling me I need to void, when there is little or no urine there." Maybe urinary problems are not due to incorrect nerve signals at all, maybe the problem lies with the muscles, spasming perhaps…

In any event, I hope the problem has been resolved.
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