oxidative stress in MS study

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

oxidative stress in MS study

Postby Cece » Fri Mar 11, 2011 4:38 pm

http://bjbms.org/archives/2011-1/6-Dzuvo.pdf

full text included

Abstract
Multiple sclerosis (MS) is a chronic infl ammatory disease of the central nervous system (CNS). It is characterized by loss of myelin, the fatty
tissue that surrounds and protects nerve fibres allowing them to conduct electrical impulses. Recent data indicate that oxidative stress (OS)
plays a major role in the pathogenesis of multiple sclerosis (MS). The aim of this study was to estimate level of serum total antioxidative capacity
in patients with multiple sclerosis. Our cross-sectional study included 33 patients with MS and 24 age and sex matched control subjects. All
our patients had a Poser criteria for definite diagnostic categories of multiple sclerosis. Serum total antioxidant capacity (TAC) was measured
by quantitative colorimetric determination, using Total antioxidant Capacity-QuantiCromAntioxidant Assay Kit (BioAssay systems, USA;
DTAC-100). Mean serum TAC in multiple sclerosis group of patients was 119.2 mM Trolox equivalents and was signifi cantly lower (p<0.001)
compared to the control group of subjects (167.1 mM Trolox equivalents). Our results showed that oxidative stress plays an important role in pathogenesis of multiple sclerosis. This finding, also, suggests the importance of antioxidants in diet and therapy of MS patients.

Apologies if this has already been discussed.
Cece
Family Elder
 
Posts: 8956
Joined: Mon Jan 04, 2010 4:00 pm

Advertisement

Postby jimmylegs » Fri Mar 11, 2011 5:01 pm

uric acid antioxidant status is low in ms patients compared to healthy controls. strong links to suboptimal zinc (also common in ms patients) and the urea cycle :)
READ ME key info on nutrient targets - www.thisisms.com/ftopict-2489.html
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com
User avatar
jimmylegs
Volunteer Moderator
 
Posts: 9225
Joined: Sat Mar 11, 2006 4:00 pm


Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users