Filmmaker wrote:I do not even understand what is this form of MS induced in the rats?.. is that demyelination? Well guess what, MS is NOT only about demylenation... as you know many other conditions cause nerve damage (such as diabetes, lupus... or whatver) but ehy do not end up in a wheelchair... so it's time for researchers to first define what IS MS...
EAE, or mouse MS as it is commonly known, is injected into the mouse's brain and the result is demylenation. In that instance, a foreign body causes the mouse's immune system to react and thus cause the lesions. But in humans, they still do not know what causes the demylenation. The conventional and long term theory is that the immune system turns on the brain cells and does the damage. More recently some researchers believe some other damaging action causes the inflamation in the brain and the person's immune system reacts to that in a normal manner.
The bottom line is that after some 70 years of research, MS has no known cause and nothing remotely close to being effective in treating it.
I watched my wife suffer from this disease year after year and only became more and more frustrated at the total lack of progress in the docs trying to find any kind of answer.