willowford i would be interested to see the studies showing that ms patients do not have urea cycle disruption and excess ammonia.
Well, any study looking at this won't be just looking for absence, they would also be looking for presence of this blood marker.
By this logic, we can list any number of potential findings and say that there is no evidence that they DON'T exist. This isn't the way things should be studied otherwise, we'd go around in circles forever because there are so many factors involved. There are MANY bodily functions and products; we can't conclude they EACH lead to MS related cognitive impairment until proven otherwise.
Are there studies that suggest that there is elevated ammonium or urea in patients with MS that is higher than the rates in those without? Case studies are important to generate more larger scale research but don't give conclusive answers since patients with MS are not immune from conditions like zinc-deficiency (or other deficiencies) that can affect others. For example, I met a patient with MS and Huntington's disease... totally separate diseases, but he just happened to have both.
iq don't personally have bloodwork demonstrating hyperammonemia, but i do have documented past low zinc, with years of low uric acid, and serious cognitive deficits (almost lost my drivers license), AND simultaneous MRI-documented lesion activity, which resolved with zinc repletion (the low uric acid normalized also).
the case study showing zinc levels at 7.65 and ammonia at ~750 is not to be taken lightly, in IMHO.
my zinc level at original baseline test was 8.6 umol/L and therefore if we are in any way comparable, you could expect my ammonia levels to be at least in the hundreds.
with the normal range for ammonia sitting at 15-45, i don't think zinc, the urea cycle, and ammonia toxicity ought to be swept aside.
Many deficiencies lead to cognitive impairment in MS and non-MS individuals. a few examples: iron, zinc, B12, folic acid...etc. the list goes on.
People without MS who have zinc deficiency of course experience symptoms. The only question is whether zinc is involved in most cases of MS cognitive dysfunction (40-65% of MS patients affected).
I was certainly not doubting or commenting on YOUR situation. I'm glad things are going well for you.
Certainly, if someone has a deficiency, whether they have MS or not, it needs to be treated. Just because someone has MS, doesn't mean they can't be affected by other common deficiencies in vitamins and minerals like anyone else.
I was commenting on the general relationship between ammonia/uric acid and MS-related cognitive dysfunction. Currently there is no direct evidence to suggest this is the case. That's all I was saying.