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The acetylcholinesterase inhibitor donepezil (Aricept) failed to improve multiple sclerosis patients' memory impairments in a placebo-controlled, multicenter trial, researchers said.

Neither patients' impressions of memory function nor their scores on an objective test of verbal memory -- the two primary outcome measures in the 120-person trial -- were better after 24 weeks of treatment with 10 mg/day of donepezil, reported Lauren Krupp, MD, of the State University of New York at Stony Brook.

The treatment also had no statistically significant benefits on secondary endpoints, although there was a trend favoring improvement in clinicians' impressions of change, she and her colleagues wrote in the April 26 issue of Neurology....Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1264

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