MRI correlates of cognitive impairment in childhood-onset MS

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MRI correlates of cognitive impairment in childhood-onset MS

Postby MSUK » Fri May 06, 2011 4:47 am



Objective: Brain MRI measures were correlated with neuropsychological function in 35 pediatric-onset multiple sclerosis (MS) patients and 33 age- and sex-matched healthy controls.

Method: Mean age of MS patients was 16.3 ± 2.3 years with average disease duration of 4.3 ± 3.1 years. Cortical gray matter, thalamic, and global brain volumes were calculated for all participants using a scaling factor computed using normalization of atrophy method to normalize total and regional brain volumes for head size. T1- and T2-weighted lesion volumes were calculated for MS patients....Read More - ... ageid/1408
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