Makes me wonder if the histamine theory has something to do with bee sting success in some people.(??)
Even if you're not allergic, bee venom remains a foreign substance and I'd think it may increase the release of histamine.
The histamine theory goes back to Dr. Hinton Jonez who gave thousands of MS patients IV histamine at his Tacoma MS Clinic from 1949-1952. The benefit that this gave MS patients at the time was quite remarkable and there wasn't one patient who ended up with any kind of severe side effect.
The sad part was Dr. Jonez died suddenly in 1952 and all of his research and work with histamine stopped abruptly and was never continued despite the success he achieved. Even back then, he debated often with the MS docs of the day who refused to recognize his success.
Today, the histamine treatment can be obtained by using the transdermal patch, Prokarin, which slowly and under control, supplies your system with the histamine diphosphate. My wife has used it for 5 1/2 years now and has had a lot of success controlling many of her MS symptoms.
One theory behind bee sting therapy is that the body produces extra histamine from the stings and thus the reason some people experience some benefit. But that is one heck of a way to get additional histamine into your system and in a very uncontrolled manner.