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Genetic analysis of a Canadian family with an extraordinarily high prevalence of multiple sclerosis suggested that a rogue tyrosine kinase may play a role in causing the disease, a researcher said here.

A rare variant in the gene for a Janus-associated kinase called TYK2 was found in four members of this family, fitting well into current theories of the disease, according to Sreeram Ramagopalan, MD, of the University of Oxford in England.

That genetic factors play a role in MS is not in doubt, but most of the genetic players remain shadowy.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1347

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