Evidence that MS patients are deficient in the T cells that normally control Epstein-Barr virus may help explain the pathogenesis of the disease, Australian researchers say.
Professor Michael Pender and colleagues at the Royal Brisbane and Women’s Hospital found the average percentage of CD8 T cells was significantly decreased in the blood of MS patients compared with healthy subjects.
They also made the “striking” discovery that the proportion of CD8 T cells declined markedly with age in MS patients compared with healthy controls,
based on their study of 64 MS patients and 68 healthy age and sex-matched subjects.
Reporting their findings in a letter in the Journal of Neurology, Neurosurgery and Psychiatry, they wrote: “What is remarkable about the CD8 T cell deficiency in MS is that normally when EBV load is increased, as it is in the blood and brain of MS patients, the CD8 T cell frequency should increase and not decrease.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1100