oh it's pretty basic - short story, b12 deficiency = cervical and thoracic lesions. i
had one of each
here's the long story (i LOVED this web site the first time i found it!!! so very, very good)
Clinically significant: < 100 pg/ml
Suspicious: < 200 pg/ml
Homocysteine & Methymalonic acid: High
Confirm biological significance of low B12 levels
Homocystieine also elevated in folate deficiency
Multifocal axonal loss & demyelination
Cervical & thoracic
Posterior column > Anterolateral & Anterior
Peripheral nerve: Axonal loss; Occasional ± demyelination
Treatment: 1 mg i.m. q 3 months
Prognosis: Stabilization, or Some improvement
Resolve within weeks
Rarely transient exacerbation after treatment
Myelopathy changes slowly if at all
at first i loved that site for the b12 but it's pretty damned awesome in other respects too. i wish i had read more and really taken it all in 5 years ago.
for example, i used to credit the b vitamins in the klenner protocol, b12 in particular, for my marked improvements in only a few days.
years later i saw a mention of vitamin e deficiency affecting position sensory and i thought OMG i was vit e deficient too, and the high dose vit E in klenner was what gave me my position sense back!!
and sure enough when you look at the vit E deficiency section of that wustl neuromuscular vitamin and nutrient syndromes web site, there it is plain as day:
Large fiber modalities
"Sensory ataxia is distinguished from cerebellar ataxia by the presence of near-normal coordination when the movement in question is visually observed by the patient, but marked worsening of coordination when the eyes are closed."
that was me to an absolute T. why would a vegan be deficient in vitamin e? well i didn't eat anywhere near enough nuts and seeds, because i was paranoid about the fat. and i used to be REALLY bad about not eating enough dark leafy greens. those days are no more
i just weigh an extra 40 pounds :S le sigh.
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com