The four CRAB drugs reduce, on average, relapses by 30%.
However, it is now recognised that damage to axons is the real problem leading to permanent disability. In addition to treatments that reduce relapses, neuro-protective agents are required to protect axons.
This research suggests that Copaxone also has a neuro-protective effect. Some time ago I posted a video featuring Dr Gavin Giovannoni of the Institute of Neurology in London. He ran through the CRAB drugs but also suggested that there was a possible neuro-proective effect with Copaxone.
Copaxone with minocycline is currently being trialled so it will be interesting to see the results as minocycline was thought to have a neuro-protective effect as well as to dampen the immune system.