Axion, you mentionned that lesions in optic nerve and spinal cord mean something in terms of prognosis, I didn't know that, Can you explain please, thanks Carole
Sorry to be so slow responding - just saw this.
I think there is still a lot of work to be done in this area.
I don't know that it was so much prognosis per se but how lesion location relates to specific symptoms that we were talking about.
Lesions on the optic nerve have a strong correlation to visual disturbances.
(wonder how much $$$ they spent on that study - seems a pretty obvious conclusion)
In general studies do indicate that lesions in the spinal chord are more likely to lead to:
sensory or motor deficits
bowel & bladder disfunction
However, it seems you still can't make the prognosis jump since even with spinal lesions at least one study showed no strong correlation between extent of plaques and the degree of clinical disability.
It would seem that with lesions in the brain there would be more opportunity for other pathways to form, so it would be tougher to predict the type of disability a lesion in a specific location would cause.
I think Wesley made a good point in that timing of the lesion is probably key as well.
As I said, I have not seen any MS studies address this. If anyone has, I'd be interested in taking a look.
So we're back to the question Bromley posed in another thread... what that all important MRI scan really means?
Still far too many unknowns!