Starving inflammatory immune cells slows damage caused by MS

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Starving inflammatory immune cells slows damage caused by MS

Postby MSUK » Fri Sep 02, 2011 1:23 am

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In a paper published today in the journal Scientific Reports, a pair of researchers at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences report that inhibiting the ability of immune cells to use fatty acids as fuel measurably slows disease progression in a mouse model of multiple sclerosis (MS).

MS is an autoimmune disease resulting from damage to the myelin sheath, a protective layer surrounding nerve cells. When the sheath is damaged, nerve impulses are slowed or halted, resulting in progressive physical and neurological disabilities. The cause of the damage is inflammation occurring when the body’s immune cells attack the central nervous system (CNS).... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1100
MS-UK - http://www.ms-uk.org/
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Postby fee001 » Fri Sep 02, 2011 5:10 am

Hi!

How can they model a mouse on ms, when there is no fact about the disease itself.

Praps I'm being a bit thick here, how can they replicate a condition 100% and gauge an experimental reaction.

I dont get it. So nothing is going to be conclusive.

Fiona (now my head hurts)
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Postby HarryZ » Fri Sep 02, 2011 5:42 am

fee001 wrote:Hi!

How can they model a mouse on ms, when there is no fact about the disease itself.

Praps I'm being a bit thick here, how can they replicate a condition 100% and gauge an experimental reaction.

I dont get it. So nothing is going to be conclusive.

Fiona (now my head hurts)


Two points...

1) The article says that MS is an autoimmune disease. This has never been proven and when I see that statement in any research paper, I immediately give it minimal credibility.

2) There has never been a successful treatment derived from positive results on the EAE mouse model. EAE and human MS are very, very different!

Harry
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Postby fee001 » Fri Sep 02, 2011 6:13 am

Harry,\

Yeah they said years ago that it was not an auto immune disease.

So who goes round saying all these things.no wonder everyone gets confused.

And who pays for all this research that goes on, on a supposidly incorrect theory in the first place.

I thought it was just me not knowing if I was coming or going.

Thanx

Fiona

P.s. Harry we need some fast hard facts, not all these possibilities, its just depressing
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Postby HarryZ » Fri Sep 02, 2011 7:47 am

P.s. Harry we need some fast hard facts, not all these possibilities, its just depressing


I'm not sure there are too many "hard facts" about MS.

Today, there is no known cause of MS. The approved therapies center on altering the immune system and their results have been, at best, spotty. There are various theories of which the researchers are arguing and accusing each other of giving wrong information about the disease.

They are still using the EAE mouse model to test various therapies because they have not developed any other model in decades. We know the results from using EAE and they are abysmal.

So "hard facts", at the moment are far and few in between.

Harry
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Postby fee001 » Fri Sep 02, 2011 10:05 am

Harry,

I know I have definitely 100% been misdiagnosed, but I only know that because I have stayed out of any existing system.

I have I suppose become reclusive, not to my family and friends but publicly I abstain, except my physio mike or Abbey or the receptionist Andrea and John my chiropractor, oh and my taxi driver Dave.

But I am very happy with that.

Fiona
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