The presenting complaint of Mg deficiency may be due to neuromuscular hyperexcitability.(2,95) ...
In Mg deficiency, there is a lower threshold for axonal stimulation and increased nerve conduction velocity, as well as increased quantity of neurotransmitter released.(98,99) Mg is also involved in calcium handling by the muscle cell. With low intracellular Mg, calcium is more readily released from the sarcoplasmic reticulum and is reaccumulated more slowly.(100,101) This results in a muscle that is more readily contractible to a given stimulus and is less able to recover from contraction, i.e., tetany prone.
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