MS-related disorders ID’d by proteomic pattern analysis

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MS-related disorders ID’d by proteomic pattern analysis

Postby MSUK » Tue Sep 20, 2011 12:13 am


Proteomic pattern analysis of cerebrospinal fluid (CSF) analysis using matrix-assisted laser desorption/ionization time-of-flight (MALDI) mass spectrometry distinguishes between similar multiple sclerosis (MS)-related disorders, according to a study published online Sept. 12th in the Annals of Neurology.

Mika Komori, M.D., from the Kyoto University in Japan, and colleagues analyzed CSF proteomic patterns from 107 patients with MS-related disorders, including relapsing remitting-MS (RRMS), primary progressive-MS (PPMS), anti-aquaporin4 antibody seropositive-neuromyelitis optica spectrum disorder (SP-NMOSD), seronegative-NMOSD with long cord lesions of spinal magnetic resonance imaging (SN-NMOSD), amyotrophic lateral sclerosis, and non-MS inflammatory neurological control diseases, using a new, unbiased biomarker discovery strategy. Magnetic bead-based enrichment of CSF peptides and proteins was followed by MALDI mass spectrometry. Multivariate statistics and pattern-matching algorithms were used to analyze the obtained spectra. These analyses were duplicated in an independent sample of 84 patients with MS-related disorders or with other neurological diseases.... Read More - ... ageid/1816
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