welcome to TIMS - sorry to hear about your girl
your list of symptoms is red flagging magnesium for me. serum magnesium levels are low in ms patients, but luckily it's a pretty easy fix.
does your daughter suffer from menstrual cramping? if so, that's one clinical sign of problems with magnesium status. here are a few more:http://ods.od.nih.gov/factsheets/magnesium
"Early signs of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, muscle contractions and cramps, seizures (sudden changes in behaviors caused by excessive electrical activity in the brain), personality changes, abnormal heart rhythms, and coronary spasms can occur [1,3-4]."
i suspect there could even be a link to magnesium status and her lumbar scoliosis. i have not found a specific study on this, but i'm not the first with the hypothesis:http://www.ctds.info/magnesium.html#rachitic
"Rachitic skeletal features are features that are associated with rickets or ricket-like conditions. ... Mg is a needed co-factor for vitamin D utilization, meaning that a lack of Mg can cause vitamin D to be unavailable to the body. The result is that a Mg deficit could, in turn, cause vitamin D deficiency symptoms. Magnesium supplementation is sometimes needed to treat rickets that have not been responsive to vitamin D or calcium treatment.
A lack of Mg would provide a logical explanation of why mitral valve prolapse, pectus excavatum, scoliosis and other rachitic skeletal features commonly appear together."
some potential routes to magnesium deficiency:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500911/
[edit: part of the problem is City water which has to have magnesium removed when present in high enough amounts to clog the works]. ... The average American diet fifty years ago contained almost twice as much magnesium as does our present diet.Drink
. Alcohol alters magnesium balance in several ways: there is decreased magnesium in the diet of most alcoholics; alcohol impairs absorption of magnesium from the gastrointestinal track; and finally, and most importantly, alcohol, even in moderation, causes an increase in renal magnesium loss.Diarrhea
. By this I mean gastrointestinal problems in general, including inflammatory bowel disease, laxative abuse, vomiting, nasogastric suction, short bowel syndromes and malabsorption.Diuretics
. This includes the use of diuretics, both osmotic and pharmacologic, as well as kidney disease. Drugs
. The fifth D is drugs. Multiple medications have been shown to increase renal magnesium loss including albuterol and other beta agonists, aminoglycoside antibiotics, carbenicillin, ticarcillin, digitalis, amphotericin B, pentamadine, cisplatin and cyclosporine.Disease
. Foremost among these is diabetes, but magnesium deficiency is also seen in hyperthyroidism, hyperaldosteronism, and hypercalcemia of any cause.Diaphoresis
. Sweat contains magnesium and excess loss through this mechanism is the reason runners cramp up.”would your daughter go to the doc just to get a magnesium test done? if so, serum level should be 0.90mmol/L at a minimum (the normal range is 0.70-1.10 so you can't let them just tell you it's 'normal' because the entire lower half of the 'normal' range is sub-optimal.
if a test is not in the cards, you might just want to recommend magnesium-rich foods, plus a magnesium glycinate supplement (the supplemental form is very important for absorption) and perhaps epsom salts baths too (follow package instructions - more is not necessarily better)
and now for some science. this study's about kids but since you mentioned 8 years back, i figure it's applicable research:
AN ASSOCIATION BETWEEN SERUM-MAGNESIUM AND TREMOR AND CONVULSIONS IN INFANTS AND CHILDRENhttp://www.thelancet.com/journals/lance ... 40-6736(68
Thirteen cases of convulsions or tremors in children with hypomagnesæmia but no associated hypocalcæmia are reported. On recovery, either spontaneously or after administration of magnesium, serum-magnesium returned to normal levels.
Physiopathology of symptomatic and latent forms of central nervous hyperexcitability due to magnesium deficiency: a current general schemehttp://www.ncbi.nlm.nih.gov/pubmed/11153899
Symptomatic forms of central nervous hyperexcitability (NHE) due to magnesium deficiency results from the sum of direct cellular effects and of local and systemic mediated effects inducing depolarization and NHE.and most importantly
Rapid recovery from major depression using magnesium treatmenthttp://www.sciencedirect.com/science/ar ... 7706001034
Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage which could manifest as depression. Magnesium treatment is hypothesized to be effective in treating major depression resulting from intraneuronal magnesium deficits. These magnesium ion neuronal deficits may be induced by stress hormones, excessive dietary calcium as well as dietary deficiencies of magnesium. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125–300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime.
Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesium deficiency is the cause of most major depression and related mental health problems
including IQ loss and addiction is enormously important to public health and is recommended for immediate further study
. Fortifying refined grain and drinking water with biologically available magnesium to pre-twentieth century levels is recommended.
FYI healthy magnesium-rich foods:http://whfoods.org/genpage.php?tname=nutrient&dbid=75
hope that helps. if you have any questions, fire away
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com