Anti-myelin immunity is commonly thought to drive multiple sclerosis, yet the initial trigger of this autoreactivity remains elusive. One of the proposed factors for initiating this disease is the primary death of oligodendrocytes. To specifically test such oligodendrocyte death as a trigger for anti-CNS immunity, we inducibly killed oligodendrocytes in an in vivo mouse model. Strong microglia-macrophage activation followed oligodendrocyte death, and myelin components in draining lymph nodes made CNS antigens available to lymphocytes. However, even conditions favoring autoimmunity—bystander activation, removal of regulatory T cells, presence of myelin-reactive T cells and application of demyelinating antibodies—did not result in the development of CNS inflammation after oligodendrocyte death. In addition, this lack of reactivity was not mediated by enhanced myelin-specific tolerance. Thus, in contrast with previously reported impairments of oligodendrocyte physiology, diffuse oligodendrocyte death alone or in conjunction with immune activation does not trigger anti-CNS immunity.
Basically---the researchers killed off oligodendrocytes in mice BUT there was no central nervous system inflammation that developed after this step. So, this can't be the first step in MS, because inflammation is a huge part of the MS disease process, at least in the beginning. They're saying the current theory that MS begins as an autoimmune attack on myelin is not correct. EAE probably isn't the right model, then. And yes, bears do go in the woods....
I've got to admit that I can't get my mind around what the researchers are saying their study implies, in addition to or maybe based on the fact that I never realized researcher assumptions involving early MS are what the researchers say they areHarryZ wrote: Still can't believe they are using that poor MS mouse to try and find the answers to this disease!! Nothing concrete has come out of these mouse experiments for decades. The more things change, the more they remain the same!
Article wrote:Anti-myelin immunity is commonly thought to drive multiple sclerosis, yet the initial trigger of this autoreactivity remains elusive. One of the proposed factors for initiating this disease is the primary death of oligodendrocytes.
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