Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
Liberation wrote:"Now Japanese Macaques could hold the key to helping people like Susan. Scientists at the Oregon National Primate Center have discovered a new herpes virus in monkeys that causes an MS like disease in Macaques.
These brain lesions are a classic indicator of inflammation in people with MS. The discovery could help scientists solve how the disease develops and stop its onset. "
http://www.stemcelldoctors.org/multiple ... ith-ms.php
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