I think it works like this.
The condition to develop MS is prepared by venous insufficiency of the neck veins draining the brains.
This breaks the BBB (in certain areas) and slows all sort of processes important in the vessel walls: feeding, transcription.
If you then get a bacteria outbreak like the Cpn (of which it is known that it may be sleeping in your body for years) or a virus (like EBV also latent), even a vaccination for Hepatitis is suspect, these [or their ligands] will attach to cellular receptors. As these dysfunction, their important role for feeding (cells, ion pump) or transcription (oligodendrocytes that then should compete to maintain the myeline and axons) gets impaired. And if severe enough, you get MS (RR).
But some may 'survive' this first stage of attack, stay reasonably ok and not get MS. But they are not there yet. Because at mid age, the gut comes up. Bacteria in the gut (you have more bacteria in your gut than cells in your body) manipulate T/B cells (the immune system). Some people get diabetes or a rheumatic disorder from this. But our problem is a compromised BBB. And these bad T/B cells are misguided and can get on the myeline. This is the second progressive phase.
In this second phase things like insulin, insulin sensitivity, cytokines, insulin resistance, etc become important.
See for example: http://www.stemcelltherapies.org/multip ... osis_3.htm
the paragraph on the leaky gut syndrome
or http://www.kennislink.nl/publicaties/af ... -donorpoep
the paragraph on LPS-productie (In Dutch but Google Translate version below)
Besides the effect on weight Vrieze also examines the influence of intestinal flora on insulin sensitivity. They, inter alia, investigates whether the composition of the intestinal flora influence on the production of lipopolysaccharide (LPS) in the intestine. This substance is released during the fermentation process. LPS, which stimulates inflammatory responses via cytokines, contributes to insulin resistance. Thus the body responds less well to insulin, leading to type 2 diabetes.
Vrieze: "I wonder if the new intestinal flora after the transplantation of poop in lean men also affects the LPS-production and thus on the sugar. If so, then we may have a new target to inhibit the production and type 2 diabetes to address. "