You're likely to have hemochromatosis (a common hereditary disease with iron accumulation that it seriously underdiagnosed), have you been tested for any of the genes? at what age did you have ferritin>120 and what was the serum Fe or transferrin saturation? what is your sister's hgb and your and your sister's uric acid?
Your sister's ferritin could be high because of inflammation rather than because of excess iron. I've seen women with lupus and iron deficiency and ferritin of 1,000. When serum Fe & hgb are high ferritin is usually full of iron, when serum Fe & hgb are low ferritin is empty (apoferritin) and labs don't differentiate them.
Pseudogout is caused by calcium pyrophosphate crystals, which are produced when the person is low in thiamine and magnesium, so instead of making necessary and soluble thiamine pyrophosphate the body makes painful crystals of CaPP.
I'm a C282Y heterozygote, so is my sister (and brother too), so we don't have classic HH.
My ferritin has always been >120, (even when heavily pregnant over 15 years ago).
It was 175, at my sickest point about 3 years ago now, iron was around 28, transferrin saturation at 62%.
My sisters ferritin sits steadily at 150, iron high 20's, TS around 36%, but we have only recently started to collect these results. Other tests don't show she has inflammation. Her iron results are
not particularly like mine, as she has high transferrin which would suggest she is anaemic(?), and this skews her transferrin saturation result.
She definitely isn't anaemic, the only correlation I can find for that is that pre-type 2 diabetes can raise transferrin. She can't donate because she has MS. She would love to try this, as it fixed me up a treat. She gets the stiff sore joints as well.
It has also been suggested that I have porphyria by one of my specialists (a rheumotologist).
That of course opens up a whole new nest of worms
I can't drink alcohol, or tolerate hormones (birth control), I can get a rash also, especially when I've taken hormones in the past. I also react to some drugs, over the past few years it's been to local anaesthetics (dental) twice. I avoid these types of things where at all possible.
Anyway, the iron reduction works really well, quite magical really