Another finding in MS, RA, lupus, Sjogrens, and fibromyalgia that would need to be explained is dysautonomia or autonomic nervous system dysfunction. The study entitled, " Autonomic Dysfunction in Multiple Sclerosis: Correlation with Disease-Related Parameters", states, "Ninety percent of the patients had symptoms related to autonomic dysfunction."
The following study concludes, "SLE and RA are associated with severe autonomic dysfunction." http://www.ncbi.nlm.nih.gov/pubmed/20422909
What is dysautonomia? Dysautonomia is a dysfunction of the autonomic nervous system. The Merck Manual states, " The autonomic nervous system is the part of the nervous system that supplies the internal organs, including the blood vessels, stomach, intestine, liver, kidneys, bladder, genitals, lungs, pupils, and muscles of the eye, heart, and sweat, salivary, and digestive glands. The autonomic nervous system controls blood pressure, heart and breathing rates, body temperature, digestion, metabolism (thus affecting body weight), the balance of water and electrolytes (such as sodium and calcium), the production of body fluids (saliva, sweat, and tears), urination, defecation, sexual response, and other processes.
A dysfunction in the autonomic nervous system can cause dizziness or light-headedness due to excessive decrease in blood pressure when a person stands (orthostatic hypotension). People may sweat less or not at all and become intolerant to heat. The eyes and mouth may become dry. After eating, a person with dysautonomia may feel prematurely full or even vomit because the stomach empties very slowly (gastroparesis). Some people pass urine involuntarily (urinary incontinence), often because the bladder is overactive. Other people have difficulty emptying the bladder (urine retention) because the bladder is underactive. Constipation may occur, or control of bowel movements may be lost. The pupils may not dilate and narrow (constrict) as light changes."
Urinary tract infections are a common symptom of MS. Autonomic dysfunction can cause the nerves of the bladder to no longer respond normally to pressure as the bladder fills with urine. As a result, urine stays in the bladder, which leads to urinary tract infections. Dysautonomia explains many of the other features of MS as well.
The autonomic nervous system is controlled by two neurotransmitters. They are adrenaline and acetylcholine. Adrenaline is the predominant sympathetic neurotransmitter, whereas acetylcholine acts in the parasympathetic periphery. Phenylalanine is necessary to produce adrenaline.
The lack of phenylalanine would explain one of the missing neurotransmitters. We will clearly show why MS patients would also lack acetylcholine, the other neurotransmitter, as we move forward.