Between January, 2003, and February, 2005, 21 patients were treated. Engraftment of white blood cells and platelets was on median day 9 (range day 8—11) and patients were discharged from hospital on mean day 11 (range day 8—13). One patient had diarrhoea due to Clostridium difficile and two patients had dermatomal zoster. Two of the 17 patients receiving alemtuzumab developed late immune thrombocytopenic purpura that remitted with standard therapy. 17 of 21 patients (81%) improved by at least 1 point on the Kurtzke expanded disability status scale (EDSS), and five patients (24%) relapsed but achieved remission after further immunosuppression. After a mean of 37 months (range 24—48 months), all patients were free from progression (no deterioration in EDSS score), and 16 were free of relapses. Significant improvements were noted in neurological disability, as determined by EDSS score (p<0•0001), neurological rating scale score (p=0•0001), paced auditory serial addition test (p=0•014), 25-foot walk (p<0•0001), and quality of life, as measured with the short form-36 (SF-36) questionnaire (p<0•0001).
Non-myeloablative autologous haemopoietic stem cell transplantation in patients with relapsing- remitting MS reverses neurological deficits, but these results need to be confirmed in a randomised trial.
cheerleader wrote:There are no studies completed to back up that claim, CV. In fact, Burt says this--As there are no completed randomized studies on HSCT for MS, the final results of both randomized trials – MIST, that compares cyclophosphamide/rATG as a second-line therapy for interferon/copaxone failures and the BEAM/ATG regimen as a predominantly third-line therapy as proposed in this issue of Multiple Sclerosis Journal – will be important to evaluate medium- and long-term outcome of both regimens, including their toxicity.
The evaluation of HSCT is far from over. We know it doesn't work in progressive MS, and we have people on here, like Chris, who have had this HSCT in RRMS, and continue to progress. It is wrong and misleading to call this a cure. It may help some people find stability for awhile...but as Harry said earlier, his wife went 20 years without MS progression with NO treatment. Until we understand why gray matter atrophies in pediatric MS, CIS and continues to atrophy-we are no closer to a cure.
MS is not about inflammation. It is about gray matter atrophy and axonal loss. I've provided links to research which backs this up in my other posts.
you are incredibly negative to anyone who is trying to look at positive results from any treatment. You also make claims that are not factual, but you believe them to be...which is great for you, but not for all.
i am out of this thread...it's been beaten to death.
good luck to all.
Moom9335 wrote:To add some dark humor to the oh so darkness that is the reality of MS,regarding a "cure" read the greekfromdetroit.com.
It will definitely lighten up this current diatribe.
Moom9335 wrote:I think Greek is seriously considering it!