Bacteriotherapy - 3 cases of MS remission

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Re: Fecal Microbiota Transplantation - 3 cases

Postby Kronk » Mon Jan 20, 2014 10:20 pm

Interesting study that may offer some answers to FMT...

[i]"Early life exposure to normal bacteria of the GI tract (gut microbes) protects against autoimmune disease in mice, according to research published on-line in the January 17 edition of Science. The study may also have uncovered reasons why females are at greater risk of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and lupus compared to males."[i]

http://www.sciencedaily.com/releases/20 ... 133003.htm
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Re: Fecal Microbiota Transplantation - 3 cases

Postby Leonard » Tue Jan 21, 2014 1:55 am

interesting article..

quote from the article: She adds, "We don't know yet how transfer of male gut microbes into females increases their testosterone, or how this process protects against autoimmunity.

well, I think the answer is simple and straightforward: more testosterone provides better (conditions for) cellular feeding.
see also the other topic New concept for MS.
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Re: Fecal Microbiota Transplantation - 3 cases

Postby cervocuit » Thu Jan 30, 2014 8:10 am

Tiffany,
I can’t tell you if you do the right thing, but i hope that you’re shure that your donor in in very good health. Clinics which perfom FMT screen donors stool for many pathogens.

I’ve emailed Taymount clinc to know if they heard about Clostridium perfringen type B in MS and if they could detect it in samples. They told me that their donor tests reveal the presence or absence of clostridia as a species. And that they had a communication from Professor Borody who says that FMT should deal with all the Clostridium species, not just c.diff.
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Re: Fecal Microbiota Transplantation - 3 cases

Postby NHE » Tue Feb 18, 2014 3:50 am

The People's Pharmacy has recently interviewed Lawrence J. Brandt, MD, discussing fecal microbiota transplants. He is Professor in the Departments of Medicine and Surgery at the Albert Einstein College of Medicine. He is chief emeritus of gastroenterology at Montefiore University Hospital in New York and a past president of the American College of Gastroenterology.

The interviews will be freely available for the next 4 weeks.

http://www.peoplespharmacy.com/PP_935FMT.mp3

http://www.peoplespharmacy.com/Brandtextended.mp3
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Re: Fecal Microbiota Transplantation - 3 cases

Postby cervocuit » Sun May 04, 2014 1:30 am

A new suspect bug that MS patients are highly enriched for.
http://www.medscape.com/viewarticle/824585
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Re: Bacteriotherapy - 3 cases of MS remission

Postby cervocuit » Thu Aug 21, 2014 8:21 am

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Re: Bacteriotherapy - 3 cases of MS remission

Postby David1949 » Fri Aug 22, 2014 2:15 pm

I've also wondered if gut bacteria could be a factor in MS.
Recently I had a colonoscopy. The preparation for it involves drinking a solution that clears out just about everything in the gut, so that there is not much other than water coming out of patient. On top of that I was taking antibiotics before and after the colonoscopy for unrelated issues. I'm thinking that combination cleared out all bacteria in the gut including the good and the bad. So then I started eating yogurt daily to repopulate the good bacteria.

So my before condition was;
-Bowel habits not bad but not as good as I would like.
-Had lots of trouble with gas.
-My self assessed EDSS is 6.

Its now been three weeks since the colonscopy and here is what I've noticed so far.
-Bowel habits steadily improved and are now very good.
-Gas is greatly reduced and is now what I would consider "normal"
-Haven't noticed any change in MS condition but will keep you posted, if anything happens.
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Re: Bacteriotherapy - 3 cases of MS remission

Postby Kronk » Fri Aug 22, 2014 8:29 pm

cervocuit wrote:A documentary on canadian TV

Gut reaction

part 1 :
http://www.abc.net.au/catalyst/stories/4067184.htm
part 2 :
http://www.abc.net.au/catalyst/stories/4070977.htm



Great video watched the full 2 parts.

Like one of the scientists said in the video, gut bacteria likely plays a part in MS triggering but is not the whole story. If FMT was more readily available I would definitely give it a shot... I don't know that I am brave enough to do it at home. Even though I have changed my share of baby diapers...
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Re: Bacteriotherapy - 3 cases of MS remission

Postby cervocuit » Sat Sep 20, 2014 4:22 am

David –

http://www.plosone.org/article/info%3Ad ... ne.0062815

According to this paper: “bowel preparation (for colonoscopy) does not have a lasting effect on the composition of the intestinal microbiota for the majority of subjects.”

The luminal (inside the gut) microbiome is different from the mucosal (the tissue of the gut) one. That’s why probiotics doesn’t have long lasting effect. They just pass through. There is sitting places in the gut taken early in life and perhaps difficult to extract.
That’s why Taymount clinic recommends repeated FMT (at least 15 over 3 weeks) for conditions like MS.

This is the abstracts of ECTRIMS 2014. (thanks JimmyLegs)
http://www.opus3.com/MSBoston_PressKit/ ... ournal.pdf

Posters on microbiome are at p.336-340 and one on Clostridium Perfringens specifically p.369

My favorite:

Gut microbiome in early pediatric multiple sclerosis: a case-control study
Conclusions: Preliminary findings indicate that in very early pediatric MS, gut microbiome composition is significantly altered, with enrichment for microbiota known to be associated with gastrointestinal infectious processes.

Not surprising !
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