Data demonstrated that by measuring time to outcomes from birth rather than from onset of MS men and women have similar disease outcomes (time to reach EDSS 6); an older age at onset is favourable; relapses do not affect long-term disability outcomes and early relapses only impact progression over the short-term. Whilst young patients with MS may gain long-term benefit from treatment with DMTs, older people may find limited benefit. Interestingly, MS relapse rates naturally decrease over time and a five year relapse-free period was common (occurring in 77% of people with relapsing remitting MS) independent of drug therapy.
Treatment succeeded in reversing some of the numbness, but there was no instant miracle, and Romney’s personal life continued to unravel. Mitt Romney took over the laundry and cooking. (Asked what kind of cook he was, sons Tagg and Josh Romney say that Mitt Romney’s go-to meals are spaghetti, and pancakes with bacon.) “He made me feel really good about the things that I couldn’t do anymore,” Romney says of her husband. “I wasn’t able to go to the grocery store. I couldn’t cook dinners. I couldn’t do anything. And he just rolled right with it and just started doing everything.”
Through all this, Ann Romney wondered how long her ability to walk, even with difficulty, would last. She recalls thinking, “I’m pretty sure I’m going to end up in a wheelchair, pretty sure I’m going to be really bad.” She resolved to take action and made a decision: “I want to do things that I love so much in life before I can’t do them anymore.”
So Romney bought a horse, Buddy. Romney is quick to tell me that Buddy wasn’t an “expensive” horse. “Having him,” she says, “was like the coolest thing in the world.”
Still very weak, she could barely ride the horse: “I could only ride, like really ride, for like five minutes” before getting too worn out.
But Romney’s affection for Buddy transformed her outlook on life and gave her a reason to push herself to climb out of bed each morning. “I noticed that I had this euphoria afterwards — it kind of got me out of that fatigue place for a little bit, just for a little time,” she says of her riding. Slowly, she began to feel slightly stronger.
I agree the story is superficial but a chemo based approach isn't age based either-
or http://www.stemcellcentre.edu.au/NewsEv ... lines.aspx
or http://www.dailytelegraph.com.au/news/n ... 6004742545
I think the trick is to knock out the B cells. Some of these approaches focus on T cells and some seem to be not much more than having a go at something.
CVfactor wrote:The idea behind using chemotherapy is to reset the faulty immune system back to a naive state to eliminate the memory mechanisms that are believed to cause MS. There are currently different approaches to this in various protocols, but chemotherapy is the unifying concept.
reallyreally wrote:The point was that she used chemo. I was only offered FDA approved treatment. (which were available in '98 when she was diagnosed). Maybe I am mistaken, but I believe I have to be in a clinical trial (which I am going to be) for a DR. to try a non approved therapy? Or, at least failed every FDA approved therapy and getting worse. Again, maybe I am wrong.
And with a little look around. The drug could have been Rituximab a "B cell" therapy. There are some articles with Dr Weiner and research with the drug. This is the drug that made it with huge success into phase 2 clinical trials. I think though, sadly, it will become generic in the next couple years. So, there will not be a phase 3.
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