Cognitive Decline and Gait

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Cognitive Decline and Gait

Postby zap » Tue Jul 17, 2012 2:33 pm

http://www.nytimes.com/2012/07/17/healt ... wanted=all

I wonder how it correlates with MS gait & cognitive issues.
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Re: Cognitive Decline and Gait

Postby cheerleader » Tue Jul 17, 2012 2:45 pm

Both diseases share hippocampal atrophy, hypoperfusion, hypometabolism, mitochondrial dysfunction, slowed cerebral bloodflow, hypoxia and neurodegeneration--which are known to affect gait and cognition.
According to Dr. Peter Stys, Alheimer's and MS share many things in common, but inflammation has thrown researchers off track. Indeed, age of onset may be the major difference between the two diseases.

Because diseases such as Alzheimer’s and Parkinson’s have a much more prominent
degenerative rather than inflammatory phenotype, the initial assumption was that a degenerative
mechanism (or mechanisms) was primarily responsible, with inflammation perhaps a secondary,
but possibly important, consequence of the degeneration. In MS, the situation is reversed:
inflammation occurs early and is very prominent in many patients, so it was naturally assumed that
autoimmunity might be causal; but, as we argue throughout this Perspective, such an assumption
may be incorrect. If MS is primarily a degenerative disorder in line with an inside-out mechanism,
why would this disease be unique in engendering such prominent and cyclic inflammation?

The differences may be related to age: Alzheimer’s disease and Parkinson’s disease present decades
later than MS, and immune responsiveness wanes with age through a process of ‘immune
senescence’ (REFS 21,87). Indeed, the responsiveness of T cells, which are known to be centrally
involved in the immunopathogenesis of MS88, appears to be particularly altered with age87.
Moreover, it is conceivable that the putative cytodegeneration involving the myelinating unit
(oligodendroglia, their processes and myelin) in MS releases debris that is more antigenic35,36,66 than
the debris that is shed from the mainly synaptic and neuronal degeneration in Alzheimer’s disease.

From "Will the Real MS Please Stand Up?" Neuroscience, July 2012 opinion piece
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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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