This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Sun May 19, 2013 1:49 am


All times are UTC - 8 hours [ DST ]




Post new topic Reply to topic  [ 1 post ] 
Author Message
PostPosted: Mon Aug 20, 2012 1:31 am 
Offline
Family Elder
User avatar

Joined: Wed Oct 14, 2009 3:00 pm
Posts: 1681
Low vitamin D & EBV immune activity may be key to MS breakthrough within 2–3 years

Image

Abstract:
Objective: Vitamin D deficiency and Epstein-Barr virus (EBV) infection may be associated with the development of multiple sclerosis (MS).

We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity in 25 individuals before the first clinical manifestation of MS.

Patients and methods:

• 56 serum samples of 25 individuals who had donated blood prior to the first clinical MS manifestation (clinically isolated syndrome (CIS))

• Four male subjects, 21 female subjects,

• Mean age 31.5 years at time of pre-CIS blood sampling;

• Mean age at disease onset 33.4 years…

….were available, covering an interval of 7.3 years-2 months (mean 31.5 months) before CIS.

In 18 of 25 patients serum samples were also obtained after established diagnosis of MS.

Longitudinal age- and gender-matched healthy blood donors (four male subjects, 21 female subjects, 39 samples, mean age 32.5 years) served as controls.

Serum 25-OH-D was measured by isotope dilution-liquid chromatography-tandem mass spectrometry. 25-OH-D levels were deconvoluted using published seasonal coefficients from a German population.

Immunoglobulin G (IgG) against Epstein-Barr virus nuclear antigen-1 (EBNA1) were assessed using commercially available ELISA.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... pageid/707

_________________
The Multiple Sclerosis Resource Centre

Squiffy's House of Fun - Laughter for Multiple Sclerosis


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 1 post ] 

All times are UTC - 8 hours [ DST ]


Related topics
 Topics   Author   Replies   Views   Last post 
There are no new unread posts for this topic. Salt may stimulate MS immune activity

Anonymoose

14

728

Thu Apr 04, 2013 7:19 am

want2bike View the latest post

There are no new unread posts for this topic. Vitamin D status predicts new brain MRI activity in MS

squiffy2

1

441

Thu Aug 30, 2012 10:16 am

tedhutchinson View the latest post

There are no new unread posts for this topic. MS not "auto-immune"--it is "normal-immune&qu

skootz

10

2198

Sat Feb 26, 2011 2:25 pm

lyndacarol View the latest post

There are no new unread posts for this topic. activity level and symptoms? tell me more

JenniferF

7

1652

Fri Sep 12, 2008 6:23 pm

JenniferF View the latest post

There are no new unread posts for this topic. mri lesions and disease activity -- your experience?

bluesky63

8

1176

Mon May 09, 2011 2:14 pm

Filmmaker View the latest post

 


Who is online

Users browsing this forum: No registered users


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to: