This Is MS Multiple Sclerosis Community: Knowledge & Support

Welcome to the world's leading forum on Multiple Sclerosis research, support, and knowledge. For over 10 years, This is MS has provided an unbiased community dedicated to Multiple Sclerosis patients, caregivers, and affected loved ones.
It is currently Sat May 25, 2013 7:13 pm


All times are UTC - 8 hours [ DST ]




Post new topic Reply to topic  [ 9 posts ] 
Author Message
PostPosted: Wed Sep 12, 2012 11:55 am 
Offline
Family Member
User avatar

Joined: Mon Nov 21, 2011 9:40 am
Posts: 72
Quote:
In multiple previously conducted clinical trials for the treatment of patients with MS, Tcelna has demonstrated one of the safest side effect profiles of any marketed or development-stage MS therapy, as well as encouraging efficacy signals indicating Opexa’s therapy may have the potential to be both safe and effective for the treatment of both SPMS and RRMS patients. In Phase I/II studies involving SPMS patients treated with Tcelna (n=36), 80 percent of the patients treated with Tcelna showed no evidence of disease progression at 24 months (a 50% improvement, with respect to patients showing evidence of disease progression, over historical controls). Following two years of treatment, a subset of these patients (n=10) reported no worsening of their physical or psychological condition. Additionally, in 21 years of cumulative follow up in the same SPMS patients treated with Tcelna, the annualized relapse rate for this same subset of patients was reduced significantly compared to baseline and only one patient experienced a relapse during this time.
Quote:


http://finance.yahoo.com/news/opexa-ini ... 8A2czQtDMD


Top
 Profile  
 
PostPosted: Wed Sep 12, 2012 12:38 pm 
Offline
Family Elder
User avatar

Joined: Sat Jul 15, 2006 3:00 pm
Posts: 607
Location: midwest U.S.
scorpions wrote:
Quote:
In multiple previously conducted clinical trials for the treatment of patients with MS, Tcelna has demonstrated one of the safest side effect profiles of any marketed or development-stage MS therapy, as well as encouraging efficacy signals indicating Opexa’s therapy may have the potential to be both safe and effective for the treatment of both SPMS and RRMS patients. In Phase I/II studies involving SPMS patients treated with Tcelna (n=36), 80 percent of the patients treated with Tcelna showed no evidence of disease progression at 24 months (a 50% improvement, with respect to patients showing evidence of disease progression, over historical controls). Following two years of treatment, a subset of these patients (n=10) reported no worsening of their physical or psychological condition. Additionally, in 21 years of cumulative follow up in the same SPMS patients treated with Tcelna, the annualized relapse rate for this same subset of patients was reduced significantly compared to baseline and only one patient experienced a relapse during this time.
Quote:


http://finance.yahoo.com/news/opexa-ini ... 8A2czQtDMD


For those wondering why we hadn't heard about it before (after the 21 years of research noted above!), it's Tovaxin with a new name. :smile: And there's a whole Tovaxin sub-forum here at ThisIsMS.

Quote:
Finally, to reflect its work in optimizing the overall manufacturing process and clinical development strategy for the program, Opexa’s lead product candidate, formerly known as Tovaxin, has been rebranded as Tcelna.

_________________
Dx'd with MS & HNPP (hereditary peripheral neuropathy) 7/03 but must have had MS for 30 yrs before that. I've never taken meds for MS or MS symptoms except 1 yr experiment on LDN. (I found diet, exercise, sleep, humor, music help me the most.)


Top
 Profile  
 
PostPosted: Wed Sep 12, 2012 12:42 pm 
Offline
Family Member
User avatar

Joined: Mon Nov 21, 2011 9:40 am
Posts: 72
Thanks for clarifying for everyone. Tovaxin(Tcelna) once again takes a step forward but one has to wonder how long before it takes its historical two steps back! Interesting though.


Top
 Profile  
 
PostPosted: Wed Sep 12, 2012 2:39 pm 
Offline
Family Member
User avatar

Joined: Wed Oct 05, 2011 11:12 pm
Posts: 83
Location: Canada
Yeah well another DMD drug with what ??? - maybe a maxiumum of 30% chance of having any positive effect.
I personally don't have much faith in Big Pharma as doing anything real for people with MS as I feel that their real interest is in making money for the "corporations" so finding a cure or an effective relief of symptoms is definitely not in the best of those greedy money making interests. :evil:


Top
 Profile  
 
PostPosted: Thu Sep 13, 2012 8:05 am 
Offline
Family Elder

Joined: Sun Aug 27, 2006 3:00 pm
Posts: 775
Location: Ireland
You know 30% reduction feels good when I used to have 4 relapses a year.....

_________________
~~~~~~~~~~~~~~~
Concussus Resurgo
~~~~~~~~~~~~~~~
RR-MS dx 1998 and Coeliac dx 2003
~~~~~~~~~~~~~~~
Copaxone, Cymbalta. EPO, Fish Oils, Vitamin D3 2000 IU daily, Cal/Mag/Zinc, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle.


Top
 Profile  
 
PostPosted: Sat Sep 15, 2012 2:12 am 
Offline
Family Elder
User avatar

Joined: Wed Jul 27, 2005 3:00 pm
Posts: 2701
Location: Sydney, Australia
Azaeleaprawn wrote:
Yeah well another DMD drug with what ??? - maybe a maxiumum of 30% chance of having any positive effect.
I personally don't have much faith in Big Pharma as doing anything real for people with MS as I feel that their real interest is in making money for the "corporations" so finding a cure or an effective relief of symptoms is definitely not in the best of those greedy money making interests. :evil:
Its not a drug.


Top
 Profile  
 
PostPosted: Sat Sep 15, 2012 6:10 pm 
Offline
Volunteer Moderator
User avatar

Joined: Sat Nov 20, 2004 4:00 pm
Posts: 2719
CureOrBust wrote:
Azaeleaprawn wrote:
Yeah well another DMD drug with what ??? - maybe a maxiumum of 30% chance of having any positive effect.
I personally don't have much faith in Big Pharma as doing anything real for people with MS as I feel that their real interest is in making money for the "corporations" so finding a cure or an effective relief of symptoms is definitely not in the best of those greedy money making interests. :evil:
Its not a drug.


...and Opexa is just a small biotech company, not 'big pharma'.


Top
 Profile  
 
PostPosted: Sun Sep 16, 2012 2:33 pm 
Offline
Volunteer Moderator

Joined: Sat Mar 11, 2006 4:00 pm
Posts: 7633
no opinions here, i just browsed here and wondered if opexa is publicly traded. short answer, yes.

_________________
my approach: no meds so far - just balanced whole foods (partial 'paleo', much less outright elimination), science, supplements, & bloodwork
my regimen - www.thisisms.com/ftopict-2489.html
www.whfoods.com, www.nutritiondata.com


Top
 Profile  
 
PostPosted: Sun Sep 16, 2012 5:18 pm 
Offline
Volunteer Moderator
User avatar

Joined: Sat Nov 20, 2004 4:00 pm
Posts: 2719
jimmylegs wrote:
no opinions here, i just browsed here and wondered if opexa is publicly traded. short answer, yes.


Yes, Opexa Therapeutics has been publicly traded for years. The former name of their company was PharmaFrontiers. Their stock has not done well historically. On April 14, 2004 they had a 1:50 reverse split. This was followed by a 1:10 reverse split on June 19, 2006.

Here is a short statement on the company's history from Wikipedia...
Quote:
Founded in 2003, the company was originally known as PharmaFrontiers Corp. In October 2004 PharmaFrontiers acquired the privately held company Opexa Pharmaceuticals Inc. In June 2006 the company changed its name to Opexa Therapeutics, Inc.

In 2009 the company sold its stem cell technology to Novartis and focused all of its attention on the continuing development of Tovaxin.


NHE


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 9 posts ] 

All times are UTC - 8 hours [ DST ]


Related topics
 Topics   Author   Replies   Views   Last post 
There are no new unread posts for this topic. well i finally did it

[ Go to pageGo to page: 1, 2 ]

REDHAIRANDTEMPER

20

2495

Sat Oct 14, 2006 3:16 pm

jimmylegs View the latest post

There are no new unread posts for this topic. Finally diagnosed...

MattB

14

2894

Thu Nov 08, 2007 6:28 pm

Shayk View the latest post

There are no new unread posts for this topic. Finally had an MRI but WITHOUT contrast

mrsjitters

6

1805

Mon Aug 23, 2010 12:50 am

kirsty23 View the latest post

There are no new unread posts for this topic. Could this finally be the cure?

Vikingquest

3

507

Mon Oct 15, 2012 7:52 am

HarryZ View the latest post

There are no new unread posts for this topic. Goji Juice finally found the show

Melody

9

1835

Tue Feb 06, 2007 8:45 am

NHE View the latest post

 


Who is online

Users browsing this forum: No registered users


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum

Search for:
Jump to:  


News News Site map Site map SitemapIndex SitemapIndex RSS Feed RSS Feed Channel list Channel list
Read hundreds of Multiple Sclerosis stories on Experience Project. Experience Project is community where people connect through their life experiences. It's made by the same people who built This is MS, on the premise that no single life experience-- like having MS-- defines a person. EP covers over 10 million true stories about every possible life experience. Find yours!


Interesting: Secret Confessions | Dream Meanings | Ask Questions, Get Answers | Song Meanings