i don't imagine my thoughts are going to be any kind of useful action items per se for this case, but from a nutritional standpoint here's what's floating around in my head - first, your sister being the youngest of nine argues the possibility of abnormal prenatal developement due to low maternal nutrient stores, and in addition, possible low neonatal liver stores of nutrients. then, possible low stores in low childhood may have been further depleted as an adult due to pregnancies, although this effect may have been temporarily averted via nutritional regimens sometimes adopted for expecting moms... together these various issues paint a less than optimal nutritional picture.
You did not imagine Michelle's life you labeled it with the quote above. Her nutrition was non existent. I am hard pressed to image a green vegetable she would consider. Mother drank excessively. I do not know much during pregnancy, yet it is suffice to say, "Mother did not care for herself very well". I singled as much out with the onset of Michelle's M.S. at 21yrs or so, but she was able to smile around it, and basically ignore those who prompted her.
Let me add as much as she was my sister, she had six sisters, (one passed with coronary disease...she was the oldest.) How bizarre that the first of nine born in the late 40's, would succumb to illness in her 40's, while the youngest of nine born in the early 60's would suffer an illness as well, and likely pass in her 40's. True! There was the first four... youngest was a boy, then nine years past, then myself and four more girls. Michelle the youngest. Same parents, two generations. The oldest sister in the second generation, closest to me has been her power of attorney and confidant. Other sisters less so, but support for her was more being addressed by they, than i. I tried to reach her spiritually, and i guess i still do.
I've discussed that i believe, that i am a liberated soul. In laymen terms there are seekers, those who are liberated, seekers after liberation, and everfree. O fifth element are those who do not, or have not ever thought to seek. As a householder or family man, i remain liberated, and often in my own times a seeker after liberation. Michelle was a simple women, who sought only to love and be loved in return. She could not have fathomed that her diet and lack of nutrition might cause her to fail as she has. In so many ways, she just lived her life without undue expectations and it was here that she smiled at me when i offered her spiritual insight. I knew that if circumstances prevailed that alluded her from thinking outside her limited horizons, she might remain disinterested in seeking such esoteric things as truth and salvation.
As this is getting somewhat winded, a hope their may be some value of sharing the above. I also wonder if, or how many, have resulted in soul searching of their own largely because of M.S. Or, those whom may have deliberately rebuked spiritually... partially because of their illness and symptoms.
If asked i would share as much regarding such things.